Edja Maria Melo de  Brito Costa, Leornado Antunes  Trindade,Alessandro Leite  Cavancanti,Bárbara Viviana  Oliveora Santos,Edeltrudes de  Oliveira Lima,Gisely Maria Freire Abílio  de Castro,Ricardo  Castro,
Chemical and antifungal analysis of essential oils and phytochemicals against Candida albicans and Candida tropicalis
Clinical Microbiology and Research
2018
2674-418X
http://dx.doi.org/10.31487/j.CMR.2018.01.005
https://www.sciencerepository.org/chemical-and-antifungal-analysis-of-essential-oils-and-phytochemicals-against-candida-albicans-and-candida-tropicalis_CMR-1-105 
Abstract: The aim of this study was to evaluate the chemical composition and antifungal activity of four essential oils
(EO) and four phytochemicals against Candida albicans and Candida tropicalis. The chemical analysis of
EO was carried out using a gas chromatograph coupled with a mass spectrometer. The antifungal evaluation
was determined by means of the disc-diffusion in agar technique. The major components found were:
eucalyptol (41.06%) and limonene (28.08%) in the EO of Cinnamomum camphora, geranial (51.17%) and
neral (36.40%) in the EO of Melissa officinalis, (E)-anethole (77.14%) in the EO of Ocinum basilicum and
citronellal (37.75%), citronellol (14.27%), citronellal (37.75%) and geraniol (18.84%) in the EO of
Cymbopogon nardus. Against C. albicans and C. tropicalis strains, essential oils and phytochemicals
produced, respectively, the following growth inhibition halos: C. camphora (11 mm; 14 mm), M. officinalis
(32 mm; 30 mm), O. basilicum (32 mm; 30 mm), C. nardus (15 mm; 30 mm), alpha pinene (35 mm; 30
mm), citral (32 mm; 25 mm), citronellal (30 mm; 30 mm) and carvacrol (30 mm; 30 mm). Monoterpenes
constitute the majority of the chemical components of essential oils tested. Phytochemicals have antifungal
activity, inhibiting the growth of C. albicans and C. tropicalis.Keywords: Biological products, Plants, medicinal Oils, Volatile, Monoterpenes, Candida.