Shi  Qiu,Aihua Zhang,Jian-hua  Miao,Hui  Sun,Guang-li  Yan,Fang-fang  Wu,Xi-jun  Wang,
Neuroprotective Effects, Biological Activities and Therapeutic Potential of Phytochemicals: A Comprehensive Review
American Journal of Medicinal Chemistry
2020
2733-2519
http://dx.doi.org/10.31487/j.AJMC.2020.01.04
https://www.sciencerepository.org/neuroprotective-effects-biological-activities-and-therapeutic-potential-of-phytochemicals_AJMC-2020-1-104 
Abstract: The incidence of neurological disorders is growing in the world together with an increased lifespan.
Nowadays, there are still no effective treatments for neurodegenerative pathology, which make necessary
to search for new therapeutic agents. Natural products, most of them used in phytochemicals from herbal
medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Numerous
herbs have been applied to neurodegenerative disease treatments as complementary and alternative
medicines. In the 21st century, omics-coupled functional pharmacology was developed for
neurodegenerative drug discovery from natural products. In this article, we firstly provide the latest
understanding of neurological disorders on risk factors, category, diagnosis and treatment, and then specially
present an overview of natural products in neuroprotective effects research from chemical biology to
pharmacological targets, and also discuss the natural products application and future challenge.Keywords: Phytochemicals, neuroprotective effects, natural products, lead drug, pharmacological targets