TY - JOUR
AR - ACO-2020-1-105
TI - Efficacy of Single Pre-Operative Dose of Glucocorticoid (125mg of Solumedrol Intravenous) in Terms of Seroma Formation in Patients Undergoing Mastectomy with Axillary Clearance For Breast Cancer: A Randomized Control Trial
AU - Abida Parveen, 
AU - Aliya, Ishaq
AU - Mariya Ishaq, 
AU - Muhammad Jamshaid Hussain Khan, 
AU - Nazia lodhi, 
AU - Rufina Soomro, 
AU - Shadab Ishaq, 
JO - Annals of Clinical Oncology
PY - 2020
DA - Mon 30, Mar 2020
SN - 2674-3248
DO - http://dx.doi.org/10.31487/j.ACO.2020.01.05
UR - https://www.sciencerepository.org/efficacy-of-single-pre-operative-dose_ACO-2020-1-105 
KW - Post mastectomy seroma formation, steroid and seroma, factors for seroma formation, how to reduce seroma formation post, mastectomy, mastectomy, seroma
AB - Objective: The study aimed to determine the efficacy of single dose of glucocorticoid (125 mg of
Solumedrol intravenous) in terms of seroma formation after mastectomy in patient with carcinoma of breast.
Study Design: Randomized control trial.
Place and Duration of Study: Study was conducted in the Department of General Surgery, Liaquat
National Hospital Karachi, Pakistan from july 1 to dec 31, 2010.
Patients and Methods: Patients were randomly divided in two groups (study and control) each group
consisting of 30 patients. Randomization was done by opening of a sealed envelope which had a slip bearing
the name of study medication (solumederol or saline as placebo) to be administered. The study group
received a single dose of inj 125mg solumedrol IV half an hour prior to surgery by resident scrub in surgery.
A similar procedure was applied to the control group and patients in controlled group were administered an
equal volume of saline intravenously. After drain removal patients in both groups were observed for a
duration of 2 weeks for sermoa formation. Detection of seroma formation was based on clinical grounds by
absence of any fluid collection at mastectomy bed as detected by manual palpation. SPSS 10 was used for
analysis.
Results: Seroma formation was observed in 66.7% (40/60) women 2 weeks post drain removal. Rate of
seroma formation was significantly low in study groups than control groups (33.3% vs. 100%; p=0.0001).
Conclusion: Single dose of steroid is efficacious in reducing the post mastectomy seroma formation.