TY - JOUR
AR - SCR-2021-5-107
TI - Retroperitoneal Hibernoma: Exhibition of Three Case Reports and Literature Review
AU - Andrea Norte,  García
AU - Eulàlia Ballester , Vázquez
AU - Lorena Cambeiro , Cabré
AU - Mireia , Solans Coll
AU - Jose Ignacio Pérez , García
AU - Montserrat Clos , Enrríquez
AU - Antonio Moral , Duarte
AU - José Antonio , González López
JO - Surgical Case Reports
PY - 2021
DA - Fri 21, May 2021
SN - 2613-5965
DO - http://dx.doi.org/10.31487/j.SCR.2021.05.07
UR - https://www.sciencerepository.org/retroperitoneal-hibernoma-exhibition-of-three-case-reports-and-literature-review_SCR-2021-5-107 
KW - Retroperitoneal hibernoma, fetal brown adipose tissue, retroperitoneal tumor, benign tumor, lipoma, liposarcoma
AB - Hibernoma is a rare benign tumor that becomes from the vestiges of fetal brown adipose tissue. It can be located on different regions of the body, being tight the most frequent. Retroperitoneal region is approximately of 9.4%. The first person to describe this histological type was Merkel. To the present, there are only described 25 cases on this location. It has a slowly growth, so it is normally asymptomatic, and it usually presents doing compression of different structures. To diagnose the MRI is the best prove, although biopsy will provide definite diagnosis describing four possible variants. Immunochemistry of MDM2, CDK4 and p16 genes is really important to do the differential diagnosis with well-differentiated liposarcoma (WDLS). Only one extensive review of hibernoma with 170 cases on different regions is published. But there is no review on literature specifically of retroperitoneal region, so this is the purpose of the current study. Following we present three more cases of retroperitoneal hibernoma that we have treat on our Mesenchymal Tumours Unit and a revision of the previously published.