TY - JOUR
AR - SCR-2019-1-109
TI - Type IV hypersensitivity reaction following Cyanoacrylate Glue Embolization (VenaSealTM) of the Great Saphenous Vein incompetence: A case report
AU - Chong , TT
AU - D. , Chua
AU - Tjun Yip , Tang 
AU - Yeo , YW
JO - Surgical Case Reports
PY - 2019
DA - Thu 28, Feb 2019
SN - 2613-5965
DO - http://dx.doi.org/10.31487/j.SCR.2019.01.009
UR - https://www.sciencerepository.org/type-iv-hypersensitivity-reaction-following-cyanoacrylate-glue-embolization-venasealtm-of-the-great-saphenous-vein-incompetence-a-case-report_SR-SCR-2019-1-109 
KW - Phlebology, VenaSeal, Cyanoacrylate glue, Chronic venous insufficiency
AB - Background: In recent years, cyanoacrylate glue embolization (CAE) (VenaSealTM, Medtronic, Santa
Rosa, USA) has emerged as an effective and safe strategy in the management of chronic venous
insufficiency and varicose veins. The most common complication is a self-limiting post-procedure phlebitis,
which often resolves in a few days. In rare instances, the rash persists for weeks and is believed be attributed
to a delayed hypersensitivity reaction to cyanoacrylate.
Method: We present a short report of a female patient who developed such a rash following CAE 3 weeks
after VenaSeal treatment.
Result: The patient made a complete self-limiting recovery of her rash after 2 weeks following expectant
management with non-steroidal anti-inflammatories (NSAID) and analgesia.
Conclusion: The VenaSealTM red skin reaction should be suspected in patients developing a rash post-CAE.
This may be related to a delayed hypersensitivity reaction to the acrylate component of the compound.