TY - JOUR
AR - SCR-2018-3-123
TI - The use of Botulinum Toxin in digital reconstruction of patients affected by Raynaud?s phenomenon
AU - Francesco , Segreto
AU - Giovanni F , Marangi
AU - Mario, Alessandri-Bonetti
AU - Paolo , Persichetti
AU - Vincenzo, Cerbone
JO - Surgical Case Reports
PY - 2018
DA - Thu 20, Dec 2018
SN - 2613-5965
DO - http://dx.doi.org/10.31487/j.SCR.2018.03.023
UR - https://www.sciencerepository.org/the-use-of-botulinum-toxin-in-digital-reconstruction-of-patients-affected-by-raynauds-phenomenon_SCR-3-123 
KW - Amputation, botulinum toxin, raynaud phenomenon, raynaud disease, surgical flap
AB - Background: Surgical reconstruction in patients affected by Raynaud’s phenomenon is a challenging
procedure due to the vascular impairment, which prevents flap survival and secondary healing. Botulinum
Neurotoxin-A showed vasodilatatory and angiogenic properties in animal studies, increasing blood flow in
flap surgery.
Case presentation: We report an off-label application of Botulinum Neurotoxin-A used for digital
reconstruction in a patient affected by Reynaud’s phenomenon, in order to enhance flap survival and avoid
digital amputation. Complete flap survival and symptomatic relief were achieved.
Conclusions: This new approach may be extremely valuable when performing flap reconstruction in
patients affected by RP, allowing for increased vascular safety as well as symptomatic improvement.