TY - JOUR
AR - RCO-2018-1-101
TI - Mini-review: Current challenges in the treatment of developmentally diverse neuroendocrine like tumors: Comparison of bronchial carcinoids and neuroblastoma
AU - Evgeniya , Morgatskaya
AU - Herman , Yeger
AU - Joyeeta , Talukdar
AU - Narges , Baluch
AU - Reza Bayat , Mokhtari
AU - Sushil , Kumar
JO - Radiotherapy and Clinical Oncology
PY - 2018
DA - Thu 18, Apr 2019
SN - 2674-2497
DO - http://dx.doi.org/10.31487/j.RCO.2018.01.001
UR - https://www.sciencerepository.org/mini-review-current-challenges-in-the-treatment-of-developmentally-diverse-neuroendocrine-like-tumors-comparison-of-bronchial-carcinoids-and-neuroblastoma_RCO-1-101 
KW - Neuroendocrine tumor, neuroblastoma, bronchial carcinoid
AB - Bronchial carcinoids (BC) derive from the pulmonary neuroendocrine cell system while neuroblastoma
(NB) derives from the neural crest and represents the peripheral nervous system. Nevertheless, their
production of serotonin and catecholamines, respectively, permits comparison as neuroendocrine tumors
(NETs). BC are most often diagnosed in adults accounting for 1–5% of all invasive lung malignancies in
the adults. NB, primarily a pediatric cancer, accounts for 7-8% of all childhood cancers with the highest
incidence in children younger than 5 years, and frequent metastasis to liver, skin, bone, and brain. The major
standard treatments for BC is surgery followed by endocrine therapy and chemotherapies. NB patients on
the other hand receive treatments according to presenting stage with chemotherapies dominant and now
newer immunotherapies at more advanced stages. In general BC are more indolent but when less
differentiated can be aggressive portending a poorer outcome. NB in contrast often present at an advanced
stage and if high stage the overall survival approaches 25% despite extensive and other therapies. Early
stage diagnosis still remains a challenge since symptomology depends on their neuroendocrine
manifestation. Here we summarize the current knowledge and challenges in the management of BC and
NB.