TY - JOUR
AR - NNB-2020-3-108
TI - Can Repurposed Polyvalent Vaccine Boosters (like BCG) Limit Dementia Progression by Modifying Microglial Activation Phenotypes?
AU - Prasanna N., de Silva
JO - Neurology and Neurobiology
PY - 2020
DA - Tue 15, Sep 2020
SN - 2613-7828
DO - http://dx.doi.org/10.31487/j.NNB.2020.03.08
UR - https://www.sciencerepository.org/can-repurposed-polyvalent-vaccine-boosters-like-bcg-limit-dementia_NNB-2020-3-108 
KW - Polyvalent vaccines, microglial activation, neurodegenerative disease
AB - This article sets out a case for considering generally available polyvalent vaccines such as BCG, MMR and
DPT to be repurposed for treating emerging cognitive decline in elderly people through reducing
neuroinflammation via microglial activation. Up to now, treatments to reduce parenchymal oligomers such
as Amyloid beta in Alzheimer’s disease have been clinically unsuccessful. Therefore, an alternative
approach to try and directly attenuate microglial activation has utility.