TY - JOUR
AR - JSO-2020-6-106
TI - Celecoxib Combined with Thalidomide in the Treatment of Refractory Neoplastic Fever in Advanced Cholangiocarcinoma: A Case Report
AU - Qiu-yuan , Liang
AU - Kaijian,  Lei
AU - Shan-Bing , Wang
AU - Yue , Ren
AU - Yan , Xu
JO - Journal of Surgical Oncology
PY - 2020
DA - Wed 23, Dec 2020
SN - 2674-3000
DO - http://dx.doi.org/10.31487/j.JSO.2020.06.06
UR - https://www.sciencerepository.org/celecoxib-combined-with-thalidomide-in-the-treatment-of-refractory-neoplastic_JSO-2020-6-106 
KW -  Celecoxib, thalidomide, neoplastic fever, cholangiocarcinoma
AB - Neoplastic fever, a common symptom of tumors, can be mainly controlled by nonsteroidal antiinflammatories (NSAIDs) and corticosteroids. However, there is no standard treatment guideline for
refractory neoplastic fever, which cannot be controlled by the medicines mentioned above. This report
presents a case of advanced cholangiocarcinoma with persistent fever lasting 3 weeks. After ineffective
treatment with various antibiotics, ibuprofen, and corticosteroids, the body temperature returned to normal
after a 48-hour treatment with celecoxib + thalidomide. Finally, the overall survival (OS) of the patient
reached 8 months with radiotherapy and chemotherapy.