TY - JOUR
AR - JSO-2019-2-109
TI - Purely Intraparenchymal Plasmacytoma: A Diagnostic Conundrum. To Operate or Radiate?
AU - Andrew  J., Kobets
AU - Emad , Eskandar
AU - James, Goodrich
AU - Patrick , Lasala
AU - Rose , Fluss
AU - Vijay , Agarwal
JO - Journal of Surgical Oncology
PY - 2019
DA - Mon 22, Jul 2019
SN - 2674-3000
DO - http://dx.doi.org/10.31487/j.JSO.2019.02.09
UR - https://www.sciencerepository.org/purely-intraparenchymal-plasmacytoma-a-diagnostic-conundrum-to-operate-or-radiate-_JSO-2019-2-109 
KW - Plasmacytoma, multiple myeloma, intraparenchymal, solitary, radiation, surgical resection
AB - Intracranial plasmacytomas are rare entities that are thought to spread to the intraparenchymal space via
pre-existing lesions from the dura or skull. Purely intraparenchymal plasmacytomas, without cranial or dural
involvement, are therefore, rarer and seem to contradict the mechanism of spread that have been attributed
to these lesions. Only a few cases of purely intraparenchymal lesions have been described in the literature,
and they represent diagnostic conundrums when identified as they mimic the radiographic appearance of
other parenchymal lesions, such as metastatic tumors or infectious collections. The authors report an unusual
case of a purely intraparenchymal plasmacytoma in the right frontal lobe of a 68-year-old female with a
known history of multiple myeloma. No evidence of extension from a cranial or dural-based lesion was
found radiographically or intraoperatively and given the non-diagnostic radiographic features of this
plasmacytoma, the diagnosis was made upon pathological examination after gross total resection. A review
of the literature on purely intraparenchymal plasmacytomas is provided and the management and prognosis
of these lesions are addressed.