TY - JOUR
AR - JICOA-2020-6-106
TI - Aggregatibacter actinomycetemcomitans and Atherosclerosis
AU - Dinh Tam , Nguyen
AU - Jack , Anesi
AU - Michelle , Steicke
AU - Yutang, Wang
JO - Journal of Integrative Cardiology Open Access
PY - 2020
DA - Thu 24, Dec 2020
SN - 2674-2489
DO - http://dx.doi.org/10.31487/j.JICOA.2020.06.06
UR - https://www.sciencerepository.org/aggregatibacter-actinomycetemcomitans-and-atherosclerosis_JICOA-2020-6-106 
KW -  Aggregatibacter, actinomycetemcomitans, atherosclerosis, periodontal disease
AB - Periodontal disease is an inflammatory condition around the teeth which affects 20-50% of the worldwide
population. In periodontal disease, the bacterial plaque destroys the epithelium of the periodontal pocket
and breaks the barrier that separates the tissue and the circulation, allowing oral bacteria and their endotoxins
and exotoxins to enter the bloodstream. This can cause health problems, such as atherosclerosis.
Aggregatibacter actinomycetemcomitans (Aa) is commonly found in patients with periodontitis and the
number of Aa is associated with atherosclerotic lesion size in humans. This review focuses on Aa and
atherosclerosis with an emphasis on the interaction of Aa with cell types involved in atherosclerosis
formation.