TY - JOUR
AR - JICOA-2020-5-107
TI - Aqueous Extract of Fagara tessmannii Engl. (Rutaceae) Exhibits Antihypertensive Activity in NO Synthase Inhibitor-Induced Hypertensive Rats
AU - Yannick , Bekono Fouda
AU - Esther Ngo Lemba,  Tom
AU - Bibi-Farouck , Aboubakar Oumarou
AU - Lohik Nguegang , Mbolang
AU - Adélaïde Marie-Noël , Tegah Kuissu
AU - Paul Désiré , Dzeufiet Djomeni
AU - Théophile , Dimo
JO - Journal of Integrative Cardiology Open Access
PY - 2020
DA - Wed 30, Sep 2020
SN - 2674-2489
DO - http://dx.doi.org/10.31487/j.JICOA.2020.05.07
UR - https://www.sciencerepository.org/aqueous-extract-of-fagara-tessmannii-engl-rutaceae-exhibits-antihypertensive_JICOA-2020-5-107 
KW - NO-deficient hypertension, dyslipidemia, coronary risk, oxidative damage, F. tessmannii
AB - Background: Most cardiovascular troubleshot ultimately result of endothelial dysfunction-induced
hypertension, an intractable problem in modern medicine. Fagara tessmannii, a shrub of the African
rainforests found in Cameroon is traditionally used to treat heart diseases and hypertension. This study
aimed to evaluate the preventive effects of the aqueous extract of F. tessmannii (AEFT) on arterial
hypertension induced by NG-Nitro-L-arginine-methyl ester (L-NAME).
Methods: Male Wistar rats received saline (5 mL.kg-1
, intraperitoneally) or L-NAME (25 mg.kg-1
;
intraperitoneally), L-NAME + AEFT (100 or 200 mg.kg-1
; orally) or captopril (20 mg.kg-1
; orally) for three
weeks. Then, blood and pulse pressures (BP and PP), heart rate, lipid profile, kidney, liver and heart function
markers and oxidative status were evaluated.
Results: AEFT (100 and 200 mg.kg-1
) prevented the increase in BP (p < 0.001), PP (p < 0.01), and heart
rate (p < 0.05) induced by L-NAME. The extract has suppressed the decline of weight gain, visceral fat and
triglyceridemia, decreased total cholesterol, increased HDL-cholesterol, and significantly reduced
(p < 0.001) atherogenic and coronary risk indicators. AEFT also improved the liver, kidney and heart
markers, nitrites levels and prevented TBARS enhancement as compared to the hypertensive group. The
remodeling of the media and fibrosis process in coronaries were also prevented by the extract.
Conclusion: These results suggest that AEFT can prevent endothelial dysfunction-induced hypertension,
dyslipidemia and associated atherogenic risks, and oxidative stress induced by L-NAME.