TY - JOUR
AR - JDMC-2019-2-103
TI - Deficient Activity of FAD-Linked Glycerophosphate Dehydrogenase in the Mitochondria of Insulin-Producing Pancreatic Islets B-Cells: A Possible Cause of the Metabolic Syndrome
AU - Willy J., Malaisse
AU - Zoheir, Mellouk
JO - Journal of Diabetes Metabolism and its Complications
PY - 2019
DA - Wed 15, Jan 2020
SN - 2674-4163
DO - http://dx.doi.org/10.31487/j.JDMC.2019.02.03
UR - https://www.sciencerepository.org/deficient-activity-of-fad-linked-glycerophosphate-dehydrogenase_JDMC-2019-2-103 
KW - Metabolic syndrome, FAD-linked glycerophosphate dehydrogenase, pancreatic islet B-cells
AB - A deficient activity of mitochondrial FAD-linked glycerophosphate dehydrogenase in insulin-producing
pancreatic islet B-cells was recently identified in selected animal models of non-insulin-dependent
diabetes mellitus. The incidence of this enzymatic defect remains however to be unambiguously
documented in type-2 diabetic patients. The present review mainly aims at speculating that the altered
recognition of nutrients, especially D-glucose, by pancreatic B-cells, as resulting from the abovementioned enzymatic perturbation could also eventually lead to the development of the metabolic
syndrome (MetS).