TY - JOUR
AR - JCMCR-2021-2-102
TI - Use of Topical Nitroglycerine in the Neonatal Population Following Peripheral Tissue Ischaemia: Case Report and Updates about Safety Concerns
AU - Mariam, Anka
AU - Therese, Saad
AU - Christelle, Tayeh
AU - Lama, Charafeddine
JO - Journal of Clinical and Medical Case Reports
PY - 2021
DA - Wed 29, Sep 2021
SN - 2733-2268
DO - http://dx.doi.org/10.31487/j.JCMCR.2021.02.02
UR - https://www.sciencerepository.org/use-of-topical-nitroglycerine_JCMCR-2021-2-102 
KW - Neonatal thrombosis, nitroglycerine, limb ischaemia
AB - Neonatal thrombosis is a well-described morbidity occurring in the neonatal intensive care unit. Critically ill neonates are most vulnerable to developing thrombosis with serious complications. Fingers and toes ischaemia secondary to vascular occlusion following central lines insertion remains an uncommon occurrence. The therapeutic approach for peripheral tissue injury using local warming, anticoagulants, thrombolytics or topical hyaluronidase showed limited benefits and potential side effects. Here we report an unusual case of finger ischaemia treated successfully using topical nitroglycerine. This complements previous reports confirming the efficacy and safety of this drug and highlighting its potential benefit in neonates.