TY - JOUR
AR - DOBCR-2019-1-103
TI - A tyrosine kinase Src; regulator of bone homeostasis
AU - Shoichiro , Kokabu
AU - Takuma , Matsubara
AU - Tatsuki , Yaginuma
JO - Dental Oral Biology and Craniofacial Research
PY - 2019
DA - Thu 28, Feb 2019
SN - 2613-4950
DO - http://dx.doi.org/10.31487/j.DOBCR.2019.01.003
UR - https://www.sciencerepository.org/a-tyrosine-kinase-src-regulator-of-bone-homeostasis_SR-DOBCR-2019-1-103 
KW - Src, Osteoclast, Osteoblast
AB - The balance of bone formation by osteoblasts and bone resorption by osteoclasts is important for bone
homeostasis. Pathologic high activity of osteoclasts and repression of bone osteoblastic bone formation
result in bone metabolic diseases such as periodontal disease. To understand the mechanism of osteoblast
and osteoclast function leads to establishment of therapy for bone metabolic disease. A tyrosine kinase Src
deficient mice shows osteopetrosis because of defect bone resorbing activity and acceleration bone
formation. This indicates Src is a key molecule to regulate bone resorption and bone formation. We discuss
about the role of Src in osteoclast and osteoblast and entire bone metabolism.