TY - JOUR
AR - COR-2022-3-104
TI - Characteristics and Outcomes of Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis Depending on Malignancy Etiology
AU - Andréa, Pastissier
AU - Jérôme, Razanamahery
AU - Sébastien, Humbert
AU - Thibaud, Soumagne
AU - Etienne, Daguindau
AU - Catherine, Chirouze
AU - Gaël, Piton
AU - Nadine , Magy-Bertrand
JO - Clinical Oncology and Research
PY - 2022
DA - Fri 12, Aug 2022
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2022.03.04
UR - https://www.sciencerepository.org/characteristics-and-outcomes-of-adult_COR-2022-3-104 
KW - Hemophagocytic lymphohistiocytosis, cancer
AB - Hemophagocytic lymphohistiocytosis (HLH) may be secondary to cancer or other conditions in adults. We aimed to compare characteristics and outcomes of secondary HLH depending on cancer status among adults. Weight loss over 10 %, headache and enlarged lymph nodes were more frequent in malignant- HLH (M-HLH). Higher phosphatase alkaline level and CRP level were present in M-HLH. Mortality rate tended to be higher in M-HLH group in the first month and during the two years follow-up. Some clinical features and biological abnormalities are associated with an increased probability of malignancy in secondary HLH among adults.