TY - JOUR
AR - COR-2020-9-106
TI - New Advances in Classical Wnt/β-Catenin Signaling in Cancer
AU - Akhlaq , Ahmad
AU - Ailin , Tao
AU - Mushtaq , Ahmed
AU - Nadia , Mushtaq
AU - Ayesha Ali , Khan
AU - Qing-Xin , Li
AU - Muhammad Wasim , Jan Khan
JO - Clinical Oncology and Research
PY - 2020
DA - Wed 30, Sep 2020
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2020.09.06
UR - https://www.sciencerepository.org/new-advances-in-classical-wntb-catenin-signaling-in-cancer_COR-2020-9-106 
KW - Wnt/β-catenin signaling, tumor, cancer stem cell, target, therapeutic strategy
AB - Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and development and
tumorigenesis. This signaling pathway has received much attention in recent years. In addition to
participating in healthy tissue and organ development, inappropriate activation of this pathway can cause a
variety of tumors and other pathologies. It also plays a critical role in many processes such as proliferation,
differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition and dry maintenance of
human tumor cells. This review introduces the underlying mechanism of Wnt signaling pathway and
highlights the most recent research progresses on the relationship between Wnt signaling pathway and
tumor. Furthermore, the intrinsic link of Wnt signaling pathway to cancer stem cells is also discussed,
aiming to curb the malignant progression of tumors from the root cause. Finally, possible clinical strategies
harnessing the classical Wnt signaling pathway as a therapeutic target are summarized.