TY - JOUR
AR - COR-2019-4-108
TI - Combination of Ruthenium Dendrimers and Acoustically Propelled Gold Nanowires as a Platform for Active Intracellular Drug Delivery Towards Breast Cancer Therapy
AU - Berta Esteban-Fernández de, Ávila
AU - Hua, Gong
AU - Joseph, Wang
AU - Natalia Sanz del, Olmo
AU - Paula, Ortega
AU - Francisco Javier de la, Mata
AU - Gulcin, Bolat
AU - Sylwia, Michlewska
AU - Tibor, Hianik
AU - Zuzana, Garaiová
JO - Clinical Oncology and Research
PY - 2019
DA - Wed 20, Nov 2019
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2019.04.08
UR - https://www.sciencerepository.org/combination-of-ruthenium-dendrimers-and-acoustically-propelled-gold-nanowires-as-a-platform-for-active-intracellular-drug-delivery-towards-b_COR-2019-4-108 
KW - Ruthenium-dendrimer, nanomotor, ultrasound, fluorescence, cancer
AB - In this work, a new class of fluorescently labeled metallodendrimers based on ruthenium and possessing
anticancer activity (FITC-CRD13) is combined with graphene oxide modified gold nanowires (GOAuNWs). The resulting complexes were tested as active intracellular transporters being propelled by
ultrasound field (US) and using breast cancer cells as a model. Energy dispersive X-ray spectroscopy
analysis confirmed the successful modification of GO-AuNWs by dendrimers as shown by the uniform
presence of ruthenium over the nanomotor structure corresponding to the ruthenium groups of FITC-CRD13.
The binding of dendrimers to the surface of GO-AuNWs was accompanied by quenching their fluorescence
signal. Upon the application of an ultrasound field (5 min, 2 V, 2.66 MHz), the complexes were propelled
towards MCF7 breast cancer cells, detaching from the GO-nanomotor surface and thus recovering the
dendrimer fluorescence signal. Fluorescence signal from US-treated samples was ~1.8 fold higher compared
to passive controls. The results obtained in this work suggest that US-propelled AuNWs lead to faster cell
internalization, hence accelerating the delivery of the carbosilane ruthenium dendrimers (CRD) payload
inside MCF7 cells.