TY - JOUR
AR - COR-2019-4-101
TI - Tight Junction Protein Junctional Adhesion Molecule-A Regulates the Expression of Receptor Tyrosine Kinase EPHA2 In Triple-Negative Breast Cancer Cells
AU - Sri HariKrishna, Vellanki
AU - Viviana, Bustos
AU - Brian J., Harvey
AU - Ann M., Hopkins
JO - Clinical Oncology and Research
PY - 2019
DA - Sat 10, Aug 2019
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2019.04.01
UR - https://www.sciencerepository.org/tight-junction-protein-Jjunctional-adhesion-molecule-a-regulates-the-expression-of-receptor-tyrosine-kinase-epha2-in-triple-negative-breast-cancer-cells_COR-2019-4-101 
KW - Triple-negative breast cancer, tumor, tetrocarcin-A, JAM-A, EPHA2, ZO-1, cell viability, anti-tumor, tight junction
AB - Breast tumors lacking expression of the human epidermal growth factor receptor-2 (HER2), progesterone
receptor (PR) and estrogen receptor (ERα) are defined as triple negative breast cancers (TNBC). A lack of
targeted therapies has impaired TNBC patient prognosis. It has previously been shown that high expression
of Junctional Adhesion Molecule-A (JAM-A) correlates with aggressive breast cancer patient phenotypes,
and that JAM-A regulates the expression of HER2 in breast cancer cells. Accordingly, we hypothesized that
JAM-A might regulate the expression of other receptor tyrosine kinases. We show for the first time that
JAM-A may regulate the expression of the EPHA2 receptor in TNBC cells and propose that this pathway
merits deeper investigation for its therapeutic value in TNBC settings.