TY - JOUR
AR - COR-2019-2-102
TI - Role of Circulating DNA in the Precocious Diagnosis of Lymphoma: an example in a Transplant-Related Aggressive Lymphoma
AU - Cristina , Zucchinetti
AU - Edoardo , Benedetti
AU - Elena , Ciabatti
AU - Enrico , Orciuolo
AU - Eugenio Mario , Ciancia
AU - Federico , Rossari
AU - Francesca , Guerrini
AU - Francesco , Caracciolo
AU - Gabriele , Buda
AU - Luca , Biavati
AU - Maria Immacolata , Ferreri
AU - Mario, Petrini
AU - Sara, Galimberti
AU - Susanna , Grassi
AU - Ugo , Boggi
JO - Clinical Oncology and Research
PY - 2019
DA - Fri 12, Apr 2019
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2019.02.02
UR - https://www.sciencerepository.org/role-of-circulating-dna-in-the-precocious-diagnosis-of-lymphoma-an-example-in-a-transplant-related-aggressive-lymphoma_COR-2019-2-102 
KW - Circulating DNA, high grade B-cell lymphoma, transplant-related lymphoma, donor cancer transmission, precocious biomarker
AB - We report the case of an aggressive non-Hodgkin lymphoma transmission from a live renal donor to her
recipient. Soon after donation, the donor developed a high-grade B cell lymphoma, and the disease became
evident also in the recipient three months thereafter, showing the same biological characteristics as
confirmed by IgH rearrangement, karyotype and chimerism analyses. In the recipient, the IgH clone
appeared in circulating cell free DNA (cfDNA), but not in peripheral blood nor in bone marrow, one month
earlier than the imaging evidence of disease.
This case supports the fundamental predictive role of molecular analysis of the plasma compartment in the
diagnosis and putatively follow up of lymphomas