TY - JOUR
AR - COR-2018-1-115
TI - The Effect of Nano-Transferosomal Hydroxyurea on 4T1 animal Breast Cancer Cell Line: An in Vitro Study
AU - Afrooz , Ahmadi
AU - Azim Akbarzadeh , Khiyavi
AU - Maral Mazloumi , Tabrizi
AU - Mohammadreza , Malekpour
AU - Nahid , Kabiry
AU - Pouria , Mohammadi
AU - Sajad , Sarvari
JO - Clinical Oncology and Research
PY - 2018
DA - Fri 25, May 2018
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2018.10.015
UR - https://www.sciencerepository.org/the-effect-of-nano-transferosomal-hydroxyurea-on-4T1-animal-breast-cancer-cell-line-an-in-vitro-study_COR-1-115 
KW - Breast cancer,  drug delivery,  cytotoxicity effects,  hydroxyurea nano-transfersomes
AB - Breast cancer considered as a major health problem in women worldwide. Despite the various
chemotherapeutic strategies, complete and effective therapy with lowest side effects didn’t reach until now.
So, in this regard, evaluation of the new treatments based on nanotechnology chemotherapeutic agent's drug
delivery gained a much attention. The aim of the present study was to formulate, optimize and investigate
the potential of novel nano-transferosomal hydroxyl urea (HU) effect on 4T1 mouse breast cancer cell line.
Nano-transfersomal HU were prepared using reverse-phase evaporation method. Then evaluated for size,
encapsulation& loading yield and drug release pattern. Cytotoxic effects of prepared Nano-drug in
compared to free standard form evaluated by MTT assay. The optimized nano-transfersomes HU
formulation showed vesicles size of 52.09±4.6 nm. Also, Encapsulation and loading yield were estimated
97.09±4.4 and 4.2±0.3 respectively. The optimized nano-transfersomes HU shows a higher cytotoxic effect
in the dose dependent manner in compared to standard HU. The present study confirmed the higher
cytotoxic effects of HU due to encapsulation (nano-transferosomal form). It was concluded that the nanotransfersomes provides an improved drug delivery in 4 T1 breast cancer cell line.