TY - JOUR
AR - COR-2018-1-106
TI - Cytomorphomertic analysis of buccal cells of steel workers exposed to chromium in south indian population
AU - D, Deepak
AU - S, Sushmitha
AU - Saranya R, Singaravelu
JO - Clinical Oncology and Research
PY - 2018
DA - Mon 02, Apr 2018
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2018.10.006
UR - https://www.sciencerepository.org/cytomorphomertic-analysis-of-buccal-cells-of-steel-workers-exposed-to-chromium-in-south-indian-population_COR-1-106 
KW - Genotoxicity,  cellular diameter,  nuclear diameter,  pap stain,  steel workers
AB - Steel workers are exposed to a mixture of chemicals and chromium (IV) and (III), which is suspected to
cause genetic damage. And to evaluate the MN assay along with the cellular diameter (CD) and nuclear
diameter (ND) in the buccal epithelial cells of workers residing in Coimbatore District, South India, using
cytomorphometric analysis. Methods: 40 samples from steel workers and 20 samples were exposed, 20 as
standardized control group were examined for frequencies of micronucleus (MN) in buccal epithelial cells.
PAP staining techniques were used to examine the nucleus and micronucleus. The frequency of micronuclei
is more in smokers group when compared to alcohol consumers. Results: The genetic damage observed in
the buccal cells of steel workers was significantly higher than in controls with cigarettes smoking in exposed
group (12.28 ± 0.61) and alcohols in exposed group (12.61 ± 0.46) while compare to that of non-smoking
and non-alcohols workers (6.94 ± 0.60 and 6.47 ± 0.44). Conclusions: Occupational exposure of chromium
from steel workers has been associated with increased genetic damage in smoking and alcohol habits
represent an additional risk factor. Exposure of chromium may be related to increased risk of cancer in steel
workers.