TY - JOUR
AR - COR-2018-1-105
TI - Cytogenetic analysis of foundry molders using the micronucleus frequency in exfoliated buccal mucosa
AU - Saranya R, Singaravelu
JO - Clinical Oncology and Research
PY - 2018
DA - Mon 02, Apr 2018
SN - 2613-4942
DO - http://dx.doi.org/10.31487/j.COR.2018.10.005
UR - https://www.sciencerepository.org/cytogenetic-analysis-of-foundry-molders-using-the-micronucleus-frequency-in-exfoliated-buccal-mucosa_COR-1-105 
KW - Micronucleus test,  Occupational exposure,  foundry workers,  Exfoliated cells,  Biological monitoring
AB - Foundry workers are exposed to chemical substances such as, PAHs, toluene, phenol, sulphur oxides, etc
which can be inhaled, absorbed or possibly ingested. Micronuclei in exfoliated buccal epithelial cells are
widely used as biomarkers of cancer risk in humans. We analyzed the frequency of Micronucleated cells
(MNC) of 100 foundry workers involved in moulding or melting processes and equal number of age and
sex matched healthy volunteers enrolled as controls. Assessment was carried out on the incidence of MNC,
binucleated cells (BNC), broken egg cells (BEC), budding cells (BC), and the other anomalies (OA), in
2000 cells per individual. The data were analyzed with SPSS, using the Mann-Whitney U-test, α = 0.05.
The mean number of anomalies in foundry workers was 2.03 ± 0.13 MNC; 8.55 ± 0.26 BNC; 9.04 ± 0.13
BEC; 0.36 ± 0.09 BC, and 19.92 ± 0.03 OA; in controls it was 0.32 ± 0.03 MNC; 5.17 ± 0.03 BNC; 5.87 ±
0.09 BEC; 0.11 ± 0.13 BC, and 11.56 ± 0.08 OA; the differences for all parameters were significant. The
non-occupational factors did not significantly influence the alterations.