TY - JOUR
AR - AJSCR-2020-1-104
TI - Human Gut Flora
AU - Abhijit, Powar
AU - Gajanan Ekbote Sir, 
AU - Namrata Joshi, 
JO - American Journal of Surgical Case Reports
PY - 2020
DA - Tue 28, Jan 2020
SN - 2674-5046
DO - http://dx.doi.org/10.31487/j.AJSCR.2020.01.04
UR - https://www.sciencerepository.org/human-gut-flora_AJSCR-2020-1-104 
KW - Intestinal microflora, immune response, synergy
AB - Background: The intestinal microflora is a complex ecosystem. An improved understanding of this hidden
organ will reveal secrets that are relevant to human health and to several infectious, inflammatory and
neoplastic disease processes. Given the ability of the immune response to rapidly counter infectious agents,
it is striking that such a large density of microbes can exist in a state of synergy within the human host.
Objective: The relevance and effect of resident bacteria on a host’s physiology and pathology are extremely
diverse. An ever-increasing body of evidence implicates the GI microbiota in defining states of health &
disease.
Materials and Methods: We review the literature in adult and pediatric GI microbiome studies, the
emerging links between microbial community structure, function, infection and disease, and the approaches
to manipulate this crucial ecosystem to improve host health.
Conclusions: Manipulation of the flora is becoming a realistic therapeutic and prophylactic strategy for
many infectious, inflammatory and even neoplastic diseases within the gut. Based on the influence of
prenatal and early postnatal microbial exposures on the developing immune response to gut microbiome,
aberrations in adulthood associated with chronic inflammatory diseases, have revealed the complexity of
our dynamic relationship with microbes.