article = {SCR-2018-3-123}
title = {The use of Botulinum Toxin in digital reconstruction of patients affected by Raynaud?s phenomenon}
journal = {Surgical Case Reports}
year = {2018}
issn = {2613-5965}
doi = {http://dx.doi.org/10.31487/j.SCR.2018.03.023}
url = {https://www.sciencerepository.org/the-use-of-botulinum-toxin-in-digital-reconstruction-of-patients-affected-by-raynauds-phenomenon_SCR-3-123 
author = {Francesco  Segreto,Giovanni F  Marangi,Mario Alessandri-Bonetti,Paolo  Persichetti,Vincenzo Cerbone,}
keywords = {Amputation, botulinum toxin, raynaud phenomenon, raynaud disease, surgical flap}
abstract ={Background: Surgical reconstruction in patients affected by Raynaud’s phenomenon is a challenging
procedure due to the vascular impairment, which prevents flap survival and secondary healing. Botulinum
Neurotoxin-A showed vasodilatatory and angiogenic properties in animal studies, increasing blood flow in
flap surgery.
Case presentation: We report an off-label application of Botulinum Neurotoxin-A used for digital
reconstruction in a patient affected by Reynaud’s phenomenon, in order to enhance flap survival and avoid
digital amputation. Complete flap survival and symptomatic relief were achieved.
Conclusions: This new approach may be extremely valuable when performing flap reconstruction in
patients affected by RP, allowing for increased vascular safety as well as symptomatic improvement.}