article = {JSO-2018-1-103}
title = {Biomechanical Study of Simulated Metastatic Peri-Acetabular Defects}
journal = {Journal of Surgical Oncology}
year = {2018}
issn = {2674-3000}
doi = {http://dx.doi.org/10.31487/j.JSO.2018.01.003}
url = {https://www.sciencerepository.org/biomechanical-study-of-simulated-metastatic-peri-acetabular-defects_JSO-1-103 
author = {Francis R.  Patterson,Jennifer  Thomson,Joseph Benevenia,Kathleen S.  Beebe,Michael N.  Kang,}
keywords = {Peri-acetabular, Harrington, biomechanical}
abstract ={Peri-acetabular metastasis presents the risk of fracture. However, the relationship between bone loss and
fracture risk is unknown. Utilizing fresh frozen intact cadaver pelves, Harrington class I lesions were
simulated. Lesions were categorized as small (<40%) or large (>40%) Axial loading was applied in a quasistatic mechanism by a mechanical testing system to catastrophic failure, with the load-to-failure force being
measured. There was statistical difference in the load-to-failure force between hemi-pelves with large
defects and their matched controls. It was found that mean load-to-failure strength of a hemi-pelvis with a
Class I defect was more than 2.3-2.45 times the calculated hip joint reactive force. Thus, it was concluded
that a pelvis with a peri-acetabular defect of greater than 40% has a significantly lower load-to-failure
strength compared to an intact pelvis. However, even this large Class I defect will fracture only at supraphysiologic loads and the hip joint may not normally be exposed to forces that high.}