article = {JDOA-2019-1-105}
title = {Gardner Syndrome: Complications/Manifestations in the Oral Cavity and Their Relationship with Oral Health}
journal = {Journal of Dentistry Open Access}
year = {2019}
issn = {2674-4155}
doi = {http://dx.doi.org/10.31487/j.JDOA.2019.01.05}
url = {https://www.sciencerepository.org/gardner-syndrome-complications-manifestations-in-the-oral-cavity_JDOA-2019-1-105 
author = {Antoine Gazelle,Inês Lopes Cardoso,}
keywords = {Gardner syndrome, familial adenomatous polyposis, colorectal cancer, APC gene, manifestations in the oral cavity}
abstract ={Gardner syndrome (GS) is a genetic disease, with autosomal dominant transmission, being a phenotypic
variant of familial adenomatous polyposis (FAP). FAP is manifested by the development of numerous
adenomas in the rectum during adolescence, and in most cases, if not identified and treated at an early stage,
lead to colorectal cancer. This syndrome has several phenotypic characteristics and among them some
changes in the oral cavity. Thus, the dentist has a preponderant role in the detection of lesions that may be
present in the oral cavity in order to make possible an early diagnosis of the disease. Some manifestations
of GS are observed at the dental level. Around 30 to 75% of GS patients present dental anomalies including
dental agenesis, including teeth, delays in teeth eruption, dentigerous cysts, odontomas, supernumerary
teeth, root fusion and hypercementosis. It is possible to see a significant difference in the presence of dental
problems between patients with GS and the general population. In order to reduce morbidity and mortality,
several types of surgery are used to eliminate the risk of colorectal cancer, preserving neighbouring
anatomical functions.}