article = {IJRGM-2025-1-101}
title = {Combined Treatment of Noninfected Diabetes-Related Foot Ulcerations with Preconditioned Autologous Platelet-Rich Plasma with the MCT System to Enhance Exosomes Release and Phototherapy: A Case Report}
journal = {International Journal of Regenerative Medicine}
year = {2025}
issn = {2613-5914}
doi = {http://dx.doi.org/10.31487/j.IJRGM.2025.01.01}
url = {https://www.sciencerepository.org/combined-treatment-of-noninfected-diabetes_IJRGM-2025-1-101 
author = {Alexandra Amesty,}
keywords = {Diabetes-related foot ulceration, platelet-rich plasma, exosomes, photothermal biomodulation, phototherapy}
abstract ={Diabetes-related foot ulceration is a common complication in patients with uncontrolled diabetes mellitus and is associated with high mortality. This case report describes an 83-year-old woman with more than 20 years of type Ib diabetes, hypertension, and five noninfected skin lesions on the lower limbs of a one-year evolution. The patient had failed previous treatments. Our treatment protocol consisted of a topical treatment using preconditioned autologous platelet-rich plasma with photothermal biomodulation using the MCT System, combined with phototherapy. The patient underwent three treatment sessions, one per week and a cleaning session four days after each treatment. The protocol applied was intended to increase the exosome released by platelets. After the three treatment sessions, the ulcers had a favorable evolution, reducing depth, size, and pain and allowing for their manipulation. The treatment had no technical difficulties or adverse effects. The patient regained mobility, which could improve her quality of life. Due to the results obtained, it can be concluded that the combined use of the topical application of preconditioned platelet-rich plasma with photothermal biomodulation using the MCT system and phototherapy could be an innovative regenerative option without immunogenic potential and low risk of complications for treating noninfected diabetes-related foot ulceration.}