article = {DOBCR-2019-1-103}
title = {A tyrosine kinase Src; regulator of bone homeostasis}
journal = {Dental Oral Biology and Craniofacial Research}
year = {2019}
issn = {2613-4950}
doi = {http://dx.doi.org/10.31487/j.DOBCR.2019.01.003}
url = {https://www.sciencerepository.org/a-tyrosine-kinase-src-regulator-of-bone-homeostasis_SR-DOBCR-2019-1-103 
author = {Shoichiro  Kokabu,Takuma  Matsubara,Tatsuki  Yaginuma,}
keywords = {Src, Osteoclast, Osteoblast}
abstract ={The balance of bone formation by osteoblasts and bone resorption by osteoclasts is important for bone
homeostasis. Pathologic high activity of osteoclasts and repression of bone osteoblastic bone formation
result in bone metabolic diseases such as periodontal disease. To understand the mechanism of osteoblast
and osteoclast function leads to establishment of therapy for bone metabolic disease. A tyrosine kinase Src
deficient mice shows osteopetrosis because of defect bone resorbing activity and acceleration bone
formation. This indicates Src is a key molecule to regulate bone resorption and bone formation. We discuss
about the role of Src in osteoclast and osteoblast and entire bone metabolism.}