article = {COR-2020-7-109}
title = {Water-soluble SCR7 Can Abrogate DNA End Joining and Induce Cancer Cell Death}
journal = {Clinical Oncology and Research}
year = {2020}
issn = {2613-4942}
doi = {http://dx.doi.org/10.31487/j.COR.2020.07.09}
url = {https://www.sciencerepository.org/water-soluble-scr7-can-abrogate-dna-end-joining-and-induce_COR-2020-7-109 
author = {Ujjayinee  Ray,Anjana  Elizabeth Jose,Rohini  Suresh,Uthara  Kaloor,Hassan A.  Swarup,Mridula  Nambiar,Sathees C. Raghavan,}
keywords = {NHEJ inhibitor, DSB repair, nonhomologous end joining, ligase IV, apoptosis, cancer therapy}
abstract ={Small molecule inhibitors targeting DNA repair pathways in cancer cells is a novel and promising approach
in cancer therapy, which can improve current therapeutic regimen. Although various attempts have been
made for designing inhibitors against DNA damage response and repair proteins, reports on
Nonhomologous End Joining (NHEJ) inhibitors are limited. Of the several chemical moieties identified,
SCR7 and its oxidized form are novel and potent DNA Ligase IV inhibitors involved in the abrogation of
DNA end joining thereby leading to cell death. In the present study, we have synthesized sodium salt of
SCR7 to generate a water-soluble version of the molecule, referred to as water-soluble SCR7 (WS-SCR7).
WS-SCR7 inhibits NHEJ in Ligase IV dependent manner, with a subtle effect on Ligase III at higher
concentration. No effect on Ligase I mediated joining was observed. WS-SCR7 shows cytotoxicity in cancer
cell lines, leading to induction of apoptosis in a dose-dependent manner.}