article = {COR-2019-4-108}
title = {Combination of Ruthenium Dendrimers and Acoustically Propelled Gold Nanowires as a Platform for Active Intracellular Drug Delivery Towards Breast Cancer Therapy}
journal = {Clinical Oncology and Research}
year = {2019}
issn = {2613-4942}
doi = {http://dx.doi.org/10.31487/j.COR.2019.04.08}
url = {https://www.sciencerepository.org/combination-of-ruthenium-dendrimers-and-acoustically-propelled-gold-nanowires-as-a-platform-for-active-intracellular-drug-delivery-towards-b_COR-2019-4-108 
author = {Berta Esteban-Fernández de Ávila,Hua Gong,Joseph Wang,Natalia Sanz del Olmo,Paula Ortega,Francisco Javier de la Mata,Gulcin Bolat,Sylwia Michlewska,Tibor Hianik,Zuzana Garaiová,}
keywords = {Ruthenium-dendrimer, nanomotor, ultrasound, fluorescence, cancer}
abstract ={In this work, a new class of fluorescently labeled metallodendrimers based on ruthenium and possessing
anticancer activity (FITC-CRD13) is combined with graphene oxide modified gold nanowires (GOAuNWs). The resulting complexes were tested as active intracellular transporters being propelled by
ultrasound field (US) and using breast cancer cells as a model. Energy dispersive X-ray spectroscopy
analysis confirmed the successful modification of GO-AuNWs by dendrimers as shown by the uniform
presence of ruthenium over the nanomotor structure corresponding to the ruthenium groups of FITC-CRD13.
The binding of dendrimers to the surface of GO-AuNWs was accompanied by quenching their fluorescence
signal. Upon the application of an ultrasound field (5 min, 2 V, 2.66 MHz), the complexes were propelled
towards MCF7 breast cancer cells, detaching from the GO-nanomotor surface and thus recovering the
dendrimer fluorescence signal. Fluorescence signal from US-treated samples was ~1.8 fold higher compared
to passive controls. The results obtained in this work suggest that US-propelled AuNWs lead to faster cell
internalization, hence accelerating the delivery of the carbosilane ruthenium dendrimers (CRD) payload
inside MCF7 cells. 
}