Table 1: Clinical, Pathologic, Molecular Features, Management and Outcome IFS.

Patient

Sex

Age (months)

 Symptoms

Site

Size

Mtts

PCR

ETV6-NTRK3

FISH ETV6

Initial surgery

IRS post 1st Sx

Chemo

2nd surgery

IRS post 2nd Sx

Event

Status 

OS

(months)

1

M

8.29

Gastrointestinal bleeding

Intestinal

<5cm

no

Positive

Positive

Complete resection

I

No

Yes

I

No

CR

25.44

2

F

1.48

Tumor

Limb

>5cm

no

Negative*

Negative

Biopsy

III

Yes

No

-

PD

SD

34

3

F

0.66

Tumor / Bleeding

Limb

>5cm

no

Positive

Positive

Biopsy

III

Yes

Yes

 II

No

SD

33.31

4

F

3.45

Shortness of breath

Trunk

>5cm

no

Positive

Positive

Biopsy

III

Yes

Yes

 I

No

CR

65.8

5

M

2.04

Tumor

Limb

>5cm

no

Positive

Positive

Partial resection

III

Yes

No

-

No

CR

15.97

6

M

0.95

Tumor

Limb

>5cm

no

Negative

Negative

Complete resection

II

No

No

-

No

CR

71.93

7

M

8.22

Tumor

Limb

<5cm

no

Positive

Positive

Complete resection

II

No

No

-

No

CR

37.84

8

M

3.98

Tumor / Bleeding

Limb

>5cm

no

Positive

Positive

Partial resection

II

Yes

Yes

I

No

CR

87.9

9

M

9.70

Tumor

H&N

<5cm

no

Negative

N/A

Biopsy

III

No

No

-

No

CR

108.23

10

M

11.31

Tumor

Limb

>5cm

lung

Positive

Positive

Biopsy

III**

Yes

No

-

Death

Death

11.12

11

M

2.27

Tumor

Limb

>5cm

no

Positive

Positive

Biopsy

III

Yes

Yes

 I

No

CR

57.83

12

F

2.60

Tumor

Trunk

>5cm

no

Negative

N/A

Complete resection

II

No

No

-

No

CR

197.41

13

M

8.26

Tumor

H&N

<5cm

no

N/A

N/A

Partial resection

III

No

No

 

No

CR

31.54

14

M

1.45

Tumor

Limb

>5cm

no

N/A

Positive

Biopsy

III

Yes

No

 

No

CR

110.72

15

F

36.41

Tumor

Limb

<5cm

no

N/A

Negative

Complete resection

I

No

No

-

No

CR

1.12

H&N: Head and Neck; PD: Progressive Disease; CR: Complete Remission; Mtts: Metastasis; SD: Stable Disease; OS: Overall Survival; N/A: Not Available Sx: Surgery.

*Recurrent fusion involving RAF1; **metastatic.