Treatment modality

Indications

Mohs micrographic surgery

The best choice of removing BCC on the eyelid with wide surgical excision

Exenteration

Bulbar or extensive orbital invasion

Radiotherapy

Combined with, when margins are not clear or followed by, exenteration of high-risk histological subtype (morphoeic/infiltrative, micronodular or basosquamous) with perineural invasion

Vismodegib

Adjuvant therapy of periocular and orbital BCC for patients who cannot tolerate surgery or radiotherapy, or with relapsed locally advanced disease after surgery or metastatic disease

Imiquimod

A topical immunotherapy for periocular BCC, especially periocular nodular BCC