Table 2: SGO guidelines for genetic risk assessment for Lynch syndrome.
|
Risk Assessment Helpful |
Risk Assessment recommended |
|
Patients with endometrial or colorectal cancer diagnosed before 50 years. Patient with endometrial or ovarian cancer with synchronous or metachronous Lynch-associated malignancies. Patients with colorectal or endometrial cancer and more than 2 first/second-degree relative meeting the above criteria. |
Patient meeting revised Amsterdam criteria.* Patient with synchronous oi metachronous colorectal and ovarian or endometrial cancers. Patient with a first/second-degree relative with a known MMR mutation. |
|
Patient with one of the above criteria have a 5-10% chance of Lynch Syndrome. |
Patient with one of the above criteria have a 20-25% chance of Lynch Syndrome. |
*Revised Amsterdam criteria are as follow: 1) at least 3 relatives with LS-associated cancer in 1 lineage 2) one affected individual is a first-degree relative of the other two 3) at least two successive affected generations 4) at least 1LS-associated cancer is diagnosed before age 50 years.