Norepinephrine first (n=3)

Vasopressin first (n=19)

P-value

Incidence of clinically significant hypotension – n (%)

1 (33.3)

15 (78.9)

0.1688

In-hospital mortality – n (%)

0 (0)

12 (63.2)

0.0779

ICU length of stay – days, median (IQR)

14 (13.5, 30.5)

12 (8.5, 22.5)

0.5530

Hospital length of stay – days, median

16 (15.5, 34)

20 (9.5, 28)

0.9708

Total duration of norepinephrine – hours, median (IQR)

66 (61.25, 68)

173 (114.1, 258.5)

<0.001

Total duration of vasopressin – hours, median (IQR)

67 (44.5, 70.25)

34 (2, 51.6)

0.4654

Total duration of vasopressors – hours, median (IQR)

88 (77.9, 90)

182.5 (127.25, 279.75)

0.0018