Endpoint

HPV

ASD

Placental Inclusions

HPV not tested but viral infections are known to cause inclusions [85]

Predictive of ASD [24]

mTOR

E6 protein activates mTORC1 [56]

(Rapamycin used medically to inhibit [59])

mTOR activated [55]

(Rapamycin used medically to inhibit [57, 58])

UBE3A

Duplicates gene that degrades p53 [61] causing genomic instability in cervical cancer [74]

Gene is duplicated in ASD [60, 62] causing genomic instability [75] and cancers

SLC4A10

Duplicates gene [44]

Duplicated gene [62] increases CSF in brain recently related to ASD [42]

Cancer

Causes several types of cancers (including children’s choroid plexus brain tumors [46] and papillomas [45])

Increased incidence of cancers in the ASD population [63, 64]

Preeclampsia

Infection increases blood pressure of pregnant women [66]

A known risk factor for ASD [65]

DNA Methylation/ genomic instability

Abnormal in cervical and only HPV+ oropharyngeal cancers [71, 72]/ genomic instability [74]

Identical twins discordant for DNA methylation [70]/genomic instability [75]