Table 1: Schedule for the experimental chronic unpredictable stress paradigm and behavioural assessment.

Chronic Unpredictable Stress Experimental Schedule
Day 1	Cage tilt & Wet bedding
Day 2	Cold swim, Restraint
Day 3	Cage agitation
Day 4	Strobe light
Day 5	Social defeat
Day 6	Predator odor
Day 7	Warm cage
Day 8	Restraint & Tail pinch, Isolation
Day 9	Isolation Begin saccharin preference testing
Day 10	Isolation & Tail pinch Behaviour testing and Tissue collection
Day 11	Strobe light
Day 12	Cold swim, Restraint
Day 13	Predator odor
Day 14	Social defeat
Day 15	Cage agitation
Day 16	Cage tilt & Wet bedding
Day 17	Warm cage
Day 18	Restraint & Tail pinch, Isolation
Day 19	Isolation Begin saccharin preference testing
Day 20	Isolation, Tail pinch Behaviour testing and Tissue collection
Day 21	Social defeat
Day 22	Warm cage
Day 23	Cold swim, Restraint
Day 24	Cage tilt & Wet bedding
Day 25	Predator odor
Day 26	Cage agitation
Day 27	Restraint & Tail pinch
Day 28	Strobe light, Isolation
Day 29	Isolation Begin saccharin preference testing
Day 30	Isolation, Tail pinch Behaviour testing and Tissue collection