Table 2: End point
total weight gain (g) and serum glucose levels (mmol/l) measured in rats (n = 6
per group) fed a normal diet (ND) for 12 weeks and injected with vehicle, and
rats fed a high fat diet (HFD) for 12 weeks and injected with vehicle or FK866
(10 mg/kg). Significant difference (one-way ANOVA): *** P < 0.001 vs. ND
rats.
|
|
ND + Vehicle |
HFD + Vehicle |
HFD + FK866 |
|
Body weight gain
(g) |
62 ± 6.5 |
183 ± 19*** |
195 ± 15*** |
|
Body weight gain
(%) |
17 ± 4.8% |
50 ± 15%*** |
49± 8.7%*** |
|
Glucose (mmol/L) |
3.9 ± 0.2 |
4.1 ± 0.2 |
4.3 ± 0.15 |