Table 4: Mapping of CDK6 residues and miRNAs.
|
Sr # |
Family |
miRNA |
Energy |
Protein Residues Mapping + mRNA Mappiing |
miRNA Residues Mapping |
|
1 |
hsa-miR-1305/ hsa-miR-1305
|
hsa-miR-1305 |
-0.16 |
ARG90 = AGA + PK-Domain ARG87 = CGA + PK-Domain ARG78 = AGG + PK-Domain ARG186 = UAC + PK-Domain GLU72 = GAG + PK-Domain PHE135 = GAC + PK-Domain TYR292 = UCU + PK-Domain VAL181 = GUC + PK-Domain ARG144 = CAU + PK-Domain ALA167 = CUU + PK-Domain LEU166 = GGC + PK-Domain GLY165 = UUC + PK-Domain GLU21 = GAG + PK-Domain SER195 = UCC + PK-Domain SER194 = CAG + PK-Domain GLN193 = CUC + PK-Domain |
UUUUCAACU A=6,7 U=1,2,3,4 C=5,8 |
|
2 |
hsa-miR-548c-5p/ miR-548-5p/559 |
hsa-miR-548ap-5P |
-7.46 |
ARG46 = CGG + PK-Domain TYR24 = UAU + PK-Domain + NB-ATP LEU96 = UUA + PK-Domain GLN193 = CAG + PK-Domain SER195 = CUA + PK-Domain TYR196 = CGC + PK-Domain ARG144 = CGC + PK-Domain PRO244 = UAG + PK-Domain |
AAAAGUAAU A=2,3,4,7,8 G=5 U=6 |
|
3 |
hsa-miR-4429/miR-320/4429 |
hsa-miR-320b |
-1.2 |
VAL179 = GUG + PK-Domain ILE169 = AUC + PK-Domain SER171 = AGU + PK-Domain TYR170 = UAU + PK-Domain TRP184 = UGG + PK-Domain GLN103 = CAA + PK-Domain TYR185 = UAC + PK-Domain ARG168 = CGC + PK-Domain GLN149 = CAG + PK-Domain PRO17 = GCG + PK-Domain LYS216 = GCC + PK-Domain LEU152 = CUG + PK-Domain LEU166 = CUU + PK-Domain GLU18 = GAG + PK-Domain GLY20 = GGG + PK-Domain + NB-ATP ILE19 = AUC + PK-Domain + NB-ATP ALA17 = GCG + PK-Domain LYS111 = AAA + PK-Domain PHE164 = UUC + PK-Domain ASN150 = AAC + PK-Domain PRO148 = CCA + PK-Domain THR106 = ACC + PK-Domain ILE151 = AUU + PK-Domain ASP110 = GAU + PK-Domain HIS100 = CAU + PK-Domain ASP104 = GAC + PK-Domain LEU105 = UUG + PK-Domain VAL101 = GUC + PK-Domain ASP102 = GAU + PK-Domain |
AAAAGCUGGG A=2,3,4 G=5,8 C=6 U=7 |
|
4 |
hsa-miR-26b-5p/miR-26-5p/1297/4465
|
hsa-miR-1297 |
-10.63 |
GLU21 = GAG + PK-Domain + NB-ATP LEU166 = CUU + PK-Domain ALA167 = GCC + PK-Domain THR107 = ACU + PK-Domain ASP110 = GAU + PK-Domain LYS111 = AAA + PK-Domain TYR196 = CGC + PK-Domain ALA197 = CAC + PK-Domain ARG140 = CGA + PK-Domain THR198 = CCC + PK-Domain HIS137 = CAU + PK-Domain SER138 = UCA + PK-Domain |
UUCAAGUAA A=4,5,8 G=6 U=2,7 C=3 |
|
5 |
hsa-miR-548k/miR-548-5p/8054 |
hsa-miR-548av-5p |
-6.29 |
ALA167 = GCC + PK-Domain GLN193 = CAG + PK-Domain ILE169 = AUC + PK-Domain VAL181 = GUC + PK-Domain ARG186 = AGA + PK-Domain ARG78 = AGG + PK-Domain HIS139 = CAC + PK-Domain GLU72 = GAG + PK-Domain SER139 = CAC + PK-Domain PHE135 = UUU + PK-Domain TYR292 = CAG + PK-Domain |
AAAAGUACU A=2,3,4,7 G=5 U=6 C=8 |
|
6 |
hsa-miR-107/miR103-3P/107 |
hsa-miR-107 |
-1.2 |
VAL179 = GUG + PK-Domain GLN193 = CAG + PK-Domain SER155 = AGC + PK-Domain SER156 = AGC + PK-Domain TYR108 = UAC + PK-Domain LYS111 = AAA + PK-Domain VAL112 = GUU + PK-Domain THR121 = ACC + PK-Domain PRO113 = CCA + PK-Domain ARG140 = CGA + PK-Domain LEU94 = CUA + PK-Domain THR84 = ACA + PK-Domain THR92 = ACC + PK-Domain VAL47 = GUG + PK-Domain PRO118 = CCC + PK-Domain |
AGCAGCAUU A=4,7 G=2,5 U=8 C=3,6
|
|
7 |
hsa-miR-21-3p/miR-21-3p/3591-p
|
hsa-miR-3591-3p |
-5.8 |
GLN193 = CAG + PK-Domain SER194 = UAG + PK-Domain SER195 = CUA + PK-Domain ARG144 = CGC + PK-Domain ALA197 = CAC + PK-Domain TYR292 = CAG + PK-Domain |
AAACACCAU A=2,3,5,8 G= -- U= -- C=4,6,7 |
|
8 |
hsa-miR-590-3p/miR-590-3p
|
hsa-miR-590-3p |
-0.93 |
ARG140 = CGA + PK-Domain SER195 = CUA + PK-Domain ALA197 = CAC + PK-Domain ASN284 = CCC + PK-Domain ALA280 = UUU + PK-Domain ARG78 = AGG + PK-Domain GLY157 = GGA + PK-Domain SER156 = AGC + PK-Domain THR121 = ACC + PK-Domain PRO118 = CCC + PK-Domain GLU120 = GAA + PK-Domain |
UAAUUUUAU A=2,3,8 G= U=4,5,6,7 C=
|
|
9 |
hsa-miR-362-3p/miR-329-3p/362-3p
|
hsa-miR-329-3P |
-2.64 |
GLU21 = GAG + PK-Domain +NB-ATP LEU166 = CUU + PK-Domain ALA167 = GCC + PK-Domain LYS111 = AAA + PK-Domain PRO113 = CCA + PK-Domain GLN193 = CAG + PK-Domain ARG144 = CGC + PK-Domain SER195 = CUA + PK-Domain VAL142 = GUG + PK-Domain TYR196 = CGC + PK-Domain ALA197 = CAC + PK-Domain THR198 = CCC + PK-Domain HIS137 = CAU + PK-Domain SER138 = UCA + PK-Domain ARG140 = CGA + PK-Domain |
AACACACCU A=2,4,6, G= U= C=3,5,7,8 |
|
10 |
hsa-miR-335-3p/miR-335-5p
|
hsa-miR-335-3p |
0.12 |
SER194 = UAG + PK-Domain ASP246 = UGU + PK-Domain GLN193 = CAG + PK-Domain VAL179 = GUG + PK-Domain ILE169 = AUC + PK-Domain TYR292 = CAG + PK-Domain |
UUUUUCAUU A=7 G= U=2,3,4,5,8 C=6 |
|
11 |
hsa-miR-33a-5p/miR-33-5p
|
hsa-miR33a-5p |
-0.81 |
ASP246 = UGU + PK-Domain GLN193 = CAG + PK-Domain SER194 = UAG + PK-Domain SER195 = CUA + PK-Domain VAL190 = GUC + PK-Domain ARG144 = CGC + PK-Domain VAL181 = GUC + PK-Domain GLU189 = GAA + PK-Domain ALA197 = CAC + PK-Domain ALA23 = GCC + PK-Domain + NB-ATP GLY22 = GGC + PK-Domain + NB-ATP ARG140 = CGA + PK-Domain VAL142 = GUG + PK-Domain VAL141 = GUA + PK-Domain HIS143 = CAU + PK-Domain |
GUGCAUUGUAGUUGCAUUGCA A=5,16 G=3,8,14,19 U=2,6,7,13,17,18 C=4,15
|
|
12 |
hsa-miR-3140-3p/miR-3140-3p
|
hsa-miR-3140-3p |
-6.79 |
VAL16 = GUG + PK-Domain VAL17 = GCG + PK-Domain PRO74 = CCC + PK-Domain TYR292 = CAG + PK-Domain SER155 = AGC + PK-Domain SER156 = AGC + PK-Domain SER293 = UGC + PK-Domain LYS279 = GUG + PK-Domain SER290 = UGC + PK-Domain LYS111 = AAA + PK-Domain ALA286 = CAA + PK-Domain LYS287 = AAG + PK-Domain |
AGCUUUUGG A= G=2,8 U=4,5,6,7 C=3
|
|
13 |
hsa-miR-3619-5p/miR-214-3p/761/3619-5p
|
hsa-miR-214-3p |
-2.26 |
THR84 = ACA + PK-Domain LEU94 = CUA + PK-Domain VAL82 = GUG + PK-Domain ALA23 = GCC + PK-Domain + NB-ATP TYR24 = UAU + PK-Domain + NB-ATP GLY22 = GGC + PK-Domain + NB-ATP ARG140 = CGA + PK-Domain VAL142 = GUG + PK-Domain VAL141 = GUA + PK-Domain ARG144 = CGC + PK-Domain TYR196 = CGC + PK-Domain ARG186 = AGA + PK-Domain VAL181 = GUC + PK-Domain ILE169 = AUC + PK-Domain LEU166 = CUU + PK-Domain ALA167 = GCC + PK-Domain LYS111 = AAA + PK-Domain TYR108 = UAC + PK-Domain VAL112 = GUU + PK-Domain GLY116 = GGA + PK-Domain PRO113 = CCA + PK-Domain PRO115 = CCU + PK-Domain PRO118 = CCC + PK-Domain VAL117 = GUG + PK-Domain THR119 = ACU + PK-Domain |
ACAGCAGGC A=3,6 G=4,7,8 U= C=2,5 |
|
14 |
hsa-miR-32-3p/miR-32-3p
|
hsa-miR-32-3p |
-5.18 |
SER194 = UAG + PK-Domain ASP246 = CUA + PK-Domain GLN193 = CAG + PK-Domain LEU166 = CUU + PK-Domain ALA167 = GCC + PK-Domain ILE169 = AUC + PK-Domain ARG168 = CGC + PK-Domain TYR292 = CAG + PK-Domain |
CAAUUUAGU A=2,3,7 G=8 U=4,5,6 C= |
|
15 |
hsa-miR-548e-3p/miR-548ar-3p/548ar-3p/548az-3p/548e-3p/548f-3p
|
hsa-miR-548e-3p |
-6.04 |
GLN193 = CAG + PK-Domain SER194 = UAG + PK-Domain SER195 = CUA + PK-Domain TYR196 = CGC + PK-Domain ALA197 = CAC + PK-Domain THR198 = CCC + PK-Domain ASP110 = GAU + PK-Domain LYS111 = AAA + PK-Domain |
AAAAACUGA A=2,3,4,5 G=8 U=7 C=6 |
|
16 |
hsa-miR-576-5p/ miR-576-5p
|
hsa-miR-576-5p |
-0.47 |
SER19 = AUC + PK-Domain TYR196 = CGC + PK-Domain ALA197 = CAC + PK-Domain ILE169 = AUC + PK-Domain |
AUUCUAAUU A=6,7 G= U=2,3,5,8 C=4 |
|
17 |
hsa-miR-548o-3p/miR-548-3p/1323 |
hsa-miR-1323 |
0.16 |
ARG140 = CGA + PK-Domain TYR196 = CGC + PK-Domain VAL142 = GUG + PK-Domain HIS137 = CAU + PK-Domain ALA23 = GCC + PK-Domain + NB-ATP GLU21 = GAG + PK-Domain + NB-ATP LEU166 = CUU + PK-Domain GLY165 = GGC + PK-Domain ARG168 = CGC + PK-Domain GLN149 = CAG + PK-Domain ASP110 = GAU + PK-Domain LYS216 = GCC + PK-Domain ARG215 = AAA + PK-Domain GLU114 = GAG + PK-Domain THR267 = AGA + PK-Domain |
CCAAAACUG A=3,4,5,6 G= U=8 C=2,7 |
|
18 |
hsa-miR-320e/miR-320
|
hsa-miR-320e |
-9.15 |
LEU166 = CUU + PK-Domain ALA167 = GCC + PK-Domain ILE169 = AUC + PK-Domain LYS111 = AAA + PK-Domain PRO113 = CCA + PK-Domain PRO118 = CCC + PK-Domain ALA23 = GCC + PK-Domain + NB-ATP ARG144 = CGC + PK-Domain SER195 = CUA + PK-Domain VAL142 = GUG + PK-Domain TYR196 = CGC + PK-Domain THR198 = CCC + PK-Domain ARG140 = CGA + PK-Domain SER138 = UCA + PK-Domain |
AAAGCUGGG A=2,3 G=4,7,8 U=6 C=5 |
|
19 |
hsa-miR-424-5p/miR-15-5p/16-5p/195-5p/424-5p/497-5p/6838-5p |
hsa-miR-15b-5p |
-5.65 |
VAL16 = GUG + PK-Domain TYR24 = UAU + PK-Domain + NB-TP ARG44 = CGC + PK-Domain ARG186 = AGA + PK-Domain ASP145 = GAU + PK-Domain HIS143 = CAU + PK-Domain ARG78 = AGG + PK-Domain GLU72 = GAG + PK-Domain LYS111 = AAA + PK-Domain SER155 = AGC + PK-Domain |
UAGCAGCAC A=2,5,8 G=3,6 U= C=4,7 |
|
20 |
hsa-miR-450b-5p/miR-450-5p |
hsa-miR-450b-5p |
-1.22 |
ARG46 = CGG + PK-Domain VAL47 = GUG + PK-Domain GLN48 = CAG + PK-Domain ALA23 = GCC + PK-Domain LEU94 = CUA + PK-Domain TYR24 = UAU + PK-Domain + NB-ATP VAL82 = GUG + PK-Domain LEU96 = UUA + PK-Domain ARG144 = CGC + PK-Domain ARG186 = AGA + PK-Domain ASP145 = GAU + PK-Domain-Active Site LEU79 = UUG + PK-Domain ARG78 = AGG + PK-Domain GLU72 = GAG + PK-Domain VAL16 = GUG + PK-Domain LYS111 = AAA + PK-Domain THR154 = ACC + PK-Domain GLN18 = GAG + PK-Domain SER155 = AGC + PK-Domain GLY157 = GGA + PK-Domain SER156 = AGC + PK-Domain |
UUUUGCAAU A=7,8 G=5 U=2,3,4 C=6
|
|
21 |
hsa-miR-142-5p/ miR-142-5p/5590-3p |
hsa-miR-142-5p |
-3.36 |
VAL147 = AAA + PK-Domain GLN48 = CAG + PK-Domain VAL45 = GUG + PK-Domain LEU94 = CUA + PK-Domain TYR24 = UAU + PK-Domain +NB-ATP ASP246 = UGU + PK-Domain GLN193 = CAG + PK-Domain ALA248 = CCU + PK-Domain VAL82 = GUG + PK-Domain LEU96 = UUA + PK-Domain LYS43 = AAG + PK-Domain + ATP-Binding Site ASP163 = GAC + PK-Domain VAL247 = UGC + PK-Domain SER194 = CCU + PK-Domain LEU79 = UUG + PK-Domain VAL142 = GUG + PK-Domain ALA162 = GCU + PK-Domain ARG140 = CGA + PK-Domain HIS143 = CAU + PK-Domain LEU161 = CUC + PK-Domain VAL141 = GUA + PK-Domain LEU136 = CUU + PK-Domain VAL76 = GUG + PK-Domain |
CAUAAAGUA A=2,4,5,6 G=7 U=3,8 C=
|
|
22 |
hsa-miR-29b-3p/miR-29-3p |
hsa-miR-29c-3p |
-6.13 |
VAL47 = GUG + PK-Domain LEU94 = CUA + PK-Domain ALA23 = GCC + PK-Domain + NB-ATP GLU21 = GAG + PK-Domain + NB-ATP GLY22 = GGC + PK-Domain + NB-ATP GLY165 = GGC + PK-Domain VAL181 = GUC + PK-Domain SER223 = AGA + PK-Domain ASP224 = UGU + PK-Domain ARG144 = CGC + PK-Domain ARG186 = AGA + PK-Domain ASP145 = GAU + PK-Domain LYS147 = AAA + PK-Domain VAL82 = GUG + PK-Domain ARG140 = CGA + PK-Domain ASP242 = CUG + PK-Domain THR198 = CCC + PK-Domain PRO199 = CGU + PK-Domain PHE283 = UAA + PK-Domain PRO238 = AGG + PK-Domain ARG288 = AAU + PK-Domain THR282 = AUU + PK-Domain ASN284 = CCC + PK-Domain PRO285 = AGC + PK-Domain ALA286 = CAA + PK-Domain LYS287 = AAG + PK-Domain ILE289 = AUC + PK-Domain LEU237 = CCC + PK-Domain GLY236 = ACU + PK-Domain LYS279 = GUG + PK-Domain |
UAGCACCAU A=2,5,8 G=3 U= C=4,6,7 |
|
23 |
hsa-miR-589-3p/miR-589-3p |
hsa-miR-589-3p |
8.2 |
LEU94 = CUA + PK-Domain CYS83 = UGC + PK-Domain VAL82 = GUG + PK-Domain THR95 = ACU + PK-Domain ASP81 = GAU + PK-Domain LEU96 = UUA + PK-Domain VAL97 = GUG + PK-Domain LEU79 = UUG + PK-Domain GLN103 = CAA + PK-Domain VAL77 = GUC + PK-Domain ALA41 = GCG + PK-Domain PHE98 = UUU + PK-Domain PHE28 = UUC + PK-Domain LYS43 = AAG + PK-Domain + ATP-Binding Site LEU42 = UUG + PK-Domain ALA23 = GCC + PK-Domain + NB-ATP LYS26 = AAG + PK-Domain + NB-ATP THR106 = ACC + PK-Domain + NB-ATP GLU21 = GAG + PK-Domain + NB-ATP GLU18 = GAG + PK-Domain VAL27 = GUG + PK-Domain + NB-ATP ALA17 = GCG + PK-Domain GLY20 = GGG + PK-Domain + NB-ATP VAL142 = GUG + PK-Domain ILE19 = AUC + PK-Domain + NB-ATP PHE164 = UUC + PK-Domain THR107 = ACU + PK-Domain HIS143 = CAU + PK-Domain LYS29 = AAG + PK-Domain VAL77 = GUC + PK-Domain HIS100 = CAU + PK-Domain GLU99 = GAA + PK-Domain ASP102 = GAU + PK-Domain ASP145 = GAU + PK-Domain ASN150 = AAC + PK-Domain LYS111 = AAA + PK-Domain ARG78 = AGG + PK-Domain ARG144 = CGC + PK-Domain ARG186 = AGA + PK-Domain ALA167 = GCC + PK-Domain VAL181 = GUC + PK-Domain VAL190 = GUC + PK-Domain THR182 = GAU + PK-Domain LEU146 = CUA + PK-Domain ARG168 = CGC + PK-Domain LYS147 = AAA + PK-Domain ILE169 = AUC + PK-Domain TYR185 = UAC + PK-Domain GLN149 = CAG + PK-Domain PRO148 = CCA + PK-Domain SER204 = GAG + PK-Domain ASP104 = GAC + PK-Domain GLN193 = CAG + PK-Domain |
UCAGAACAA A=3,5,6,8 G=4 U= C=2,7
|