Table 2: Correlation of TBX2, CHK2, and p53 expression levels with clinicopathological variables in MPNST.
|
Clinical parameters |
|
TBX2 |
|
CHK2 |
|
p53 |
||||||
|
High expression |
Low expression |
χ2 |
P |
High expression |
Low expression |
χ2 |
P |
High expression |
Low expression |
χ2 |
P |
|
|
Gender |
|
|
0.332 |
0.565 |
|
|
0.115 |
0.735 |
|
|
0.094 |
0.759 |
|
Male (35) |
20 |
15 |
|
|
16 |
19 |
|
|
10 |
25 |
|
|
|
Female (28) |
18 |
10 |
|
14 |
14 |
|
9 |
19 |
|
|||
|
Age |
|
|
0.653 |
0.419 |
|
|
0.050 |
0.824 |
|
|
0.018 |
0.893 |
|
>=40 years (39) |
22 |
17 |
|
|
19 |
20 |
|
|
12 |
27 |
|
|
|
<40 years (24) |
16 |
8 |
|
11 |
13 |
|
7 |
17 |
|
|||
|
NF1 No (58) Yes (5) Tumor site |
33 5 |
25 0 |
3.573
5.621 |
0.059
0.060 |
27 3 |
31 2 |
0.334
0.295 |
0.563
0.863 |
17 2 |
41 3 |
0.250
1.208 |
0.617
0.547 |
|
Head and neck (10) |
3 |
7 |
|
|
4 |
6 |
|
|
4 |
6 |
|
|
|
Trunk (26) |
19 |
7 |
|
13 |
13 |
|
6 |
20 |
|
|||
|
Extremity (27) |
16 |
11 |
|
13 |
14 |
|
9 |
18 |
|
|||
|
Tumor size |
|
|
0.239 |
0.887 |
|
|
0.890 |
0.641 |
|
|
3.651 |
0.161 |
|
<5cm (24) |
14 |
10 |
|
|
13 |
11 |
|
|
4 |
20 |
|
|
|
5-10cm (22) |
14 |
8 |
|
9 |
13 |
|
9 |
13 |
|
|||
|
>10cm (16) |
9 |
7 |
|
7 |
9 |
|
6 |
10 |
|
|||
|
AJCC stage |
|
|
13.761 |
0.003 |
|
|
2.470 |
0.481 |
|
|
0.991 |
0.803 |
|
Ⅰ-Ⅱ (39) Ⅲ-Ⅳ (21) |
16 19 |
23 2 |
|
|
19 8 |
20 13 |
|
|
11 6 |
28 15 |
|
|
|
Radiotherapy |
|
|
1.841 |
0.175 |
|
|
0.322 |
0.571 |
|
|
0.105 |
0.746 |
|
Yes (25) |
18 |
7 |
|
|
11 |
14 |
|
|
7 |
18 |
|
|
|
No (33) |
18 |
15 |
|
17 |
16 |
|
8 |
25 |
|
|||
|
Chemotherapy |
|
|
0.070 |
0.792 |
|
|
0.244 |
0.621 |
|
|
1.266 |
0.261 |
|
Yes (25) |
16 |
9 |
|
|
13 |
12 |
|
|
5 |
20 |
|
|
|
No (33) |
20 |
13 |
|
15 |
18 |
|
11 |
22 |
|
|||
|
Surgical type |
|
|
2.797 |
0.094 |
|
|
0.249 |
0.618 |
|
|
0.285 |
0.593 |
|
Wide resection (40) |
21 |
19 |
|
|
20 |
20 |
|
|
13 |
27 |
|
|
|
Subtotal resection (23) |
17 |
6 |
|
10 |
13 |
|
6 |
17 |
|
|||
|
Recurrence |
|
|
4.291 |
0.038 |
|
|
1.046 |
0.306 |
|
|
0.001 |
0.971 |
|
Yes (40) |
28 |
12 |
|
|
21 |
19 |
|
|
12 |
28 |
|
|
|
No (23) |
10 |
13 |
|
9 |
14 |
|
7 |
16 |
|
|||
|
Metastasis |
|
|
15.918 |
0.000 |
|
|
0.088 |
0.767 |
|
|
0.018 |
0.893 |
|
Yes (24) |
22 |
2 |
|
|
12 |
12 |
|
|
7 |
17 |
|
|
|
No (39) |
16 |
23 |
|
18 |
21 |
|
12 |
27 |
|
|||