Study type

Overall

N=251

HFpEF

n=47

HFmrEF

(n= 44)

HFrEF

(n= 160)

P

Demography/history

Sex (Males) (%)

162 (64.5)

30 (63.8)

24 (54.5)

108 (67,5)

0.28

Age (Years)

55.5 ± 16.3

62.1 ± 17*

60 ± 15.2

52.2 ±15.5 §

< 0.001

Age > 70 years

51 (20.3)

18 (38.3)*

12 (27.3)

21 (13.1) ) §

< 0.001

First episode of HF (%)

119 (47.4)

28 (59.6)*

26 (59.1)

65 (40.6) §

0.017

History of hospitalisation

46 (18.3)

8 (17)

8 (18.2)

30 (18.8)

0.96

Tobacco (%)

24 (9.6)

2 (4.3)

1 (2.3)

21 (13.1)

0.037

Physical exam

NYHA 4

233 (92.8)

150 (93.8)

42 (95.5)

41 (87.2)

NS

SBP (mm Hg)

138.9 ± 43.4

159.8 ± 37.8*

145 ± 36.9

130.9 ± 44

<0.001

SBP ≥ 140 mm Hg

128 (53.3)

32 (71.1)

27 (65.9)

69  (44.8)

0.002

SBP < 100 mm Hg

300 (12.1)

1 (2 .1)

2 (4.5)

27 (16.9)

0.006

DBP (mm Hg)

90.9 ± 26.4

95.8 ± 22.8

94.3 ± 23.2

88.5 ± 26.4

 0.16

Pulse pressure (mm Hg)

48 ± 24.7

64.1 ± 27.9*

51.1 ± 22.7 †

42.4 ± 22 §

< 0.001

Heart Rate (bpm)

101.3 ±28.5

96.7 ± 27.2

106.7 ± 28.8

101.2 ± 28.8

Heart Rate > 120 bpm

62 (25.2)

9 (19.9)

14 (32.6)

39 (24.8)

0.36

Acute Pulmonary Edema (%)

35 (13.9)

13 (27.7)*

4 (9.2) †

18 (11.3)

0.01

Biventricular heart failure

164 (65.3)

20 (42.6)*

33 (75) †

111 (69.4)

0.001

Cardiogenic shock

23 (9.2)

1 (2.1)*

2 (4.5)

20 (12.5) §

0.04

Echocardiography

LVEDD (mm)

62.3 ± 10

50 ± 8.1*

59.1 ± 7.6†

66.7 ± 7.3 §

< 0.001

LVESD (mm)

50.6 ± 12.1

32.2 ± 7.3*

45.5 ± 7.1†

57.3 ± 7.3 §

< 0.001

LVEF

0.38 ± 0.15

0.63 ± 0.08*

0.45 ± 0.03†

0.29 ± 0.06 §

< 0.001

Left atrium (mm)

47.2 ± 8.3

46.3 ± 11.2

46.7 ± 8.7

47.7 ±7.3

0.6

Left atrium enlargement

44 (17.9)

16 (34.8)

9 (20.9)

19 (12.1)

0.002

Pulmonary Hypertension

126 (50.4)

14 (30.4)

20 (47.5)

92 (57.5)

0.004

Biology

Glycemia (mmol/L)

6.88 ± 4.05

6.94 ± 3.94

7.44 ± 6.10

6.71 ± 3.50

0.61

Haemoglobin (g/dl)

12.5 ± 2.4

12.2 ± 2.7

11.8 ±2.6

12.8 ± 2.2

0.03

Natremia (mmol/L)

135.2 ± 6.1

136 ± 6.4

135.8 ± 5.3

134.8 ± 6.1

0.32

Natremia < 130 mmol/L

41 (16,3)

3 (6.4) *

3 (6.8)

35 (21.9) §

0.007

Kaliemia (mmol/L)

4.2 ± 0.7

4.3 ± 0.9

3.9 ± 0.5

4.2 ± 0.7

0.02

Kaliemia > 5.5 mmol/L

11 (4.4)

5 (10.6)

0 (50)

6 (3.8)

0,038

Creatinin (µmol/L)

129.9 ± 103.4

178.6 ± 187.4*

116.7 ± 63.6†

119.3 ± 68.9

0.01

eGRF (ml/min)

65.1 ± 30.5

62.1 ± 33.5

62.1 ± 23.6

66.8 ± 30.6

0.51

Severe renal failure ¹

30 (12)

10 (21.7)

2 (4.8)

18 (11.8)

0.05

Aetiology

Dilated CM

66 (26.3)

1 (2.1)*

5 (11.4)

60 (37.5) §

< 0.001

Hypertensive CM

129 (48.6)

29 (61.7)*

24 (54.5)

69 (43.1)§

< 0.001

Coronary Heart Disease

24 (9.6)

8 (17.6)

6 (13.6)

10 (6.3)

0.52

comorbidities

High Blood Pressure

136 (53.8)

36 (74.5)*

30 (68.2)

70 (43.8)§

< 0.001

*Diabetes Mellitus (%)

41 (16.3)

12 (25.5)*

10 (22.7)

19 (11.8) §

0.038

PAD

10 (4%)

1 (2.8)

3 (6.8)

6 (.3.8)

NS

Obesity

31 (12.4)

14 (29.8)*

4 (9.1) †

13 (8.1)

< 0.001

Dyslipidemia

95 (37.8)

19 (40.4)

20 (45.5)

56 (35)

0.41

HyperLDLemia

18 (7.2)

6 (12.8))

6 (13.6))

17 (10.6)

0.82

Hypo HDLemia

66 (26.3)

12 (17.5)

15 (34.1)

39 (24.4)

0.43

Hyper triglyceridemia

4 (1.6)

2 (4.3)

0 (0)

2 (1.3)

#

Hyperuricemia

86 (34,3)

19 (40.4)

13 (29.5)

54 (33.8)

0.53

*Renal failure

111 (44.2)

22 (42.5)

21 (47.7)

68 (48.8)

0.76

Anemia

101 (40.1)

22 (46.8)

19 (43.2)

60 (37.5)

0.47

VIH infection

29 (11.6)

5 (10.6)

2 (4.5)

22(13.8)

0.23

Atrial Fibrillation

70 (27.9)

17 (36.2)

15(34.1)

38 (23.8)

0.15

Stroke

25 (10)

3 (6.4)

3 (6.8)

19 (11.9)

0.4

Hepatic dysfunction

67 (26.7)

5 (10.6)*

8 (18,8)

53 (33.8) §

0.003

*Number of Comorbidities

3.6 ± 1.8

4.2 ± 1.7*

3.9 ± 2.1

3.3 ± 1.7

0.004

Length of stay in hospital

8.5 ± 5.2

7.1 ± 2.9

7.8 ± 4.6

8.4 ± 5.8

0.31