Table 1: Sample characteristics of infective endocarditis among COVID-19 patients with/without non-medical opioid use.

 

Before Propensity Score Matching

After Propensity Score Matching

 

Opioid Use

No Use

p-value

Opioid Use

No Use

p-value

 

n =32,388

n=1,599,127

 

n =32,388

n =32,388

 

 

n (%)

n (%)

 

n (%)

n (%)

 

Female

16,643(51.4%)

931,797 (58.3%)

<.0001

16,643 (51.4%)

16,788 (51.8%)

0.2543

White

23,129 (71.4%)

988,395 (61.8%)

<.0001

233,129 (74.1%)

23,036(71.1%)

0.4194

Black

5,980 (18.5%)

265,907 (16.6%)

<.0001

5,980 (18.5%)

6,161(19.0%)

0.0684

Chronic lower RD1

11,254 (34.7%)

196,455 (12.3%)

<.0001

11,254 (34.7%)

11,332 (35.0%)

0.5202

Diabetes

5,719 (17.7%)

108,270 (6.8%)

<.0001

5,719 (17.7%)

5,743 (17.7%)

0.8048

BMI

7,973 (24.6%)

177,554 (11.1%)

<.0001

7,973 (24.6%)

8,052 (24.9%)

0.4719

Nicotine dependence

18,970 (58.6%)

139,324 (8.7%)

<.0001

18,970 (58.6%)

18,977 (58.6%)

0.9555

SES1

7,844 (24.2%)

51,559 (3.2%)

<.0001

7,844 (24.2%)

7,835(24.2%)

0.9342

Incident IE

580 (1.8%)

1,503 (0.09%)

 

580 (1.8%)

85 (0.2%)

 

 

Mean (SD)

Mean (SD)

 

Mean (SD)

Mean (SD)

 

Age (years)

41.6 ± 10.9

38.6 ± 12.4

<.0001

41.6 ± 10.9

41.7 ± 10.9

0.6832

1Note acronyms: CI: confidence Interval; IE: infective endocarditis; n: number; s: standard deviation; RD: respiratory diseases; BMI: body mass index in kg/m2;

SES: socioeconomic status, this variable included person’s potential health hazards related to socioeconomic and psychosocial circumstances. The study includes data reported between 27 January 2020 and 20 January 2021.

Factors matched were sex, race, body mass index, nicotine dependence, age, chronic respiratory diseases, and socioeconomic status.