Table 1: Common genes found in zebrafish and cause of sudden death syndrome in humans.
|
Zebrafish Genes |
Protein |
Function |
Syndromes |
References |
|
SCN5A |
Nav1.5 |
INa, AP, Ph0 |
BrS LQTS |
Channelopathies [1, 2, 6, 38, 41, 72-78] |
|
KCNK1-3-4 |
TWK-1/2; TASK-1; TRAAK |
IKP, AP, Ph0, Ph1, Ph2, Ph3, Ph4 |
SQTS LQTS |
|
|
KCNH2 |
HERG |
IKr, AP, Ph3 |
BrS LQTS SQTS |
|
|
KCNJ2/12 |
Kir 2.1/2.2 |
IK1, AP, Ph3, Ph4 |
LQTS SQTS |
|
|
KCNJ3/5 |
Kir 3.1/3.4 |
IKAch, AP, Ph4 |
LQTS |
|
|
KCNQ1 |
KVLQT1 |
IKs, AP, Ph3 |
LQTS SQTS |
|
|
CACNA1C |
Cav1.2 |
ICa,L, AP, Ph2 |
BrS LQTS SQTS |
|
|
RyR2 |
Ryanodine receptor |
Calcium release |
ARVD CPVT |
Cardiomyopathy [74-76, 79-83] |
|
Sarcomeric genes: cmlc1, amhc, myl7, vmhc, ttn, tnnt2 |
Troponin T, Titin. myosin light chain, |
Contractility |
HCM |
INa: Sodium current; IKr: the fast component of delayed rectifier potassium current; IKs: the slow component of delayed rectifier potassium current; IK1: the inward rectifier potassium current; IKAch: The acetylcholine-activated inward rectifier potassium current; IKP: leak K+ currents; ICa,L: L-type calcium current; AP: Action potential; Ph0: Phase 0; Ph1: Phase 1; Ph2: Phase 2; Ph3: Phase 3; Ph4: Phase 4; BrS : Brugada syndrome; LQTS: Long QT syndrome; SQTS: Short QT syndrome; ARVD: arrhythmogenic right ventricular dysplasia; CPVT: catecholaminergic polymorphic ventricular tachycardia; HCM: hypertrophic cardiomyopathy.