Table 1: Diagnostic criteria for POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes). Diagnosis requires the presence of both mandatory majors, at least 1 other major and 2 minor criteria.

MANDATORY MAJOR CRITERIA	Polyneuropathy
MANDATORY MAJOR CRITERIA	Monoclonal plasma proliferative disorder
OTHER MAJOR CRITERIA	Sclerotic bone lesions
	Castleman disease
	Elevated serum Vascular Endothelial Growth Factor (VEGF) levels
MINOR CRITERIA	Papilledema
	Organomegaly (splenomegaly, lymphadenopathy etc.)
	Extravascular volume overload (pleural effusion, peripheral edema etc.)
	Skin changes
	Endocrinopathy (adrenal, thyroid, pituitary etc.)
KNOWN ASSOCIATIONS	Thrombocytosis