Table 2: Differential actions of antioxidants and cannabidiol (CBD).
Action of Antioxidants |
Action of CBD |
Donate electron to molecules with unpaired electron |
Antagonist to CB1R and agonist to CB2R |
Activate ROS-resistant Nrf2 |
Elevates anandamide which acts as an agonist to CB1R and CB2R |
Enhance the expression of microRNAs |
Acts as an agonist to dopamine, serotonin, and adenosine receptors |
Alter gene expression |
Acts as an antagonist to glutamate Receptors |
Reduce release and toxicity of glutamate |
Activates PPAR-gamma |
Reduce pro-inflammatory cytokines |
Acts as an inhibitor of serotonin-re-uptake |
|
Increases expression of genes coding for anti-inflammatory cytokines |
|
Activates NGF receptor |
|
Week antioxidant and ant-inflammation activities |
CB1R: Cannabinoid receptor CB1; Nrf2: Nuclear factor-erythroid-2-related factor-2; PPAR-gamma: Peroxisome proliferator-activator receptor-gamma; NGF: Nerve growth factor.