Study

(Author, Year)

No. of Patients

AJCC Staging

5-year Survival

Recurrence Rate (%)

Recurrence

Median Survival (months)

Resection (Y/N, %)

Chemotherapy

(Y/N, %)

Weissferdt et al., 2017 [38]

86

IA: 5 patients (5.8%)

IB: 9 patients (10.5%)

IIA: 12 patients (14.0%)

IIB: 32 patients (37.2%)

IIIA: 22 patients (25.6%)

IIIB: 3 patients (3.5%)

IV: 2 patients (2.3%)

NK 1 patient (1.2%)

34.60%

NR

NR

15

Yes, 100%

Yes, 27% neoadjuvant, 60% adjuvant

Roesel et al., 2017 [39]

58

IA: 4 patients (8.7%),

IB: 7 patients (15.2%),

IIA: 9 patients (19.6%),

IIB:15 patients (32.6%),

III: 7 patients (15.2%)

IV: 4 patients (8.7%)

28.70%

60.90%

Local: 8 patients

Distant:12 patients

Both: 8 patients

Stage I: 44.9

Stage II: 14.9

Stage III: 10.2

Stage IV: 5.6

Yes, 79.3%

Yes, 31%

Steuer et al., 2017 [40]

7965

I: patients (18%),

II: patients (10%),

III: patients (24%),

IV: patients (48%)

14.40%

NR

NR

6.4

Yes, 38%

Yes, 39%

Lococo et al., 2016 [41]

148

I: 36 patients (24%)

II: 69 patients (47%)

III: 33 patients (22%)

IV: 10 patients (7%)

12.6%

70%

Local: 58% of cases

Distant: 81% of cases

19

Yes, 100%

Yes, 67%

Gu et al., 2015 [42]

95

I: patients (24.2%)

II: patients (27.4%)

III: patients (31.6%)

IV: patients (16.8%)

21%

NR

NR

11.54

Yes, 92.6%

Yes, 37.9%

Mochizuki et al., 2008 [43]

70

I: 23 patients (33%)

II: 22 patients (31%)

III: 20 patients (29%)

IV: 5 patients (7%)

36.7%

58.5%

Local: 29% of cases

Bone: 29% of cases

Brain: 25% of cases

Pleura: 17% of cases

Liver: 17% of cases

Thorax and Neck Lymph Nodes: 8% of cases

Adrenal glands: 8% of cases

Stomach: 4% of cases

Jejunum: 4% of cases

Skin: 4% of cases

23

Yes, 100%

NR

Martin et al., 2007 [5]

63

IA: patients (8%)

IB: patients (19%)

IIA: patients (0%)

IIB: patients (30%)

IIIA: patients (22%)

IIIB: patients (16%)

IV: patients (5%)

24.5%

62.5%

Local: 21% of cases

Distant: 51% of cases

17.4

Yes, 100%

Yes, 24% pre-operative chemo

Venissac et al., 2007 [44]

39

IB:15 patients (38.5%)

IIB:14 patients (35.9%)

IIIA: 7 patients (17.9%)

IIIB: 2 patients (5.1%)

IV: 1 patient (2.6%)

33%

53.8%

Local: 10 cases

Brain: 9 cases

Bone: 6 cases

Lung: 4 cases

Bowel: 2 cases

Suprarenal Gland: 1 case

11

Yes, 100%

Yes, 43.6%