Table 4: Effect of diazepam, phenylephrine and their combinations on the locomotor activity of rats in the open field test.
|
Substance |
Dose, i.g. mg/kg |
Horizontal activity* |
Vertical activity** |
|
Control (distilled water) |
|
15.0±1.9 |
5.0±0.6 |
|
Diazepam |
3 |
10.8±1.5 |
3.6±0.6 |
|
Diazepam |
10 |
2.8±0.62 |
0.6±0.21 |
|
phenylephrine |
0.3 |
18.4±0.2 |
6.0±0.7 |
|
1.0 |
20.5±0.3 |
6.6±0.8 |
|
|
Diazepam + phenylephrine |
3 0.3 |
14.1±0.5 |
4.5±0.7 |
|
Diazepam + phenylephrine |
10 0.3 |
12.0±0.2 |
4.0±0.6 |
|
Diazepam + phenylephrine + lidocaine, 1 ml 1% |
10 0.3 |
3.0±0.62 |
0.6±0.21 |
*Total walking time (in seconds.
**Number of stands-up on the hind legs.
1p <0.01 compared with the control.
2