Table 3: Effect of diazepam, phenylephrine and their combinations on severity of pentylenetetrazole-induced seizures, as well as the number of rats with clonic-tonic and clonic seizures.
|
Substance |
Dose, i.g. mg/kg |
Average severity of PTZ-induced seizures, in points |
The number of rats with PTZ-induced seizures in % of the total number of rats in the group |
|
|
Clonico-tonic seizures* |
Clonic seizures** |
|||
|
Control (distilled water) |
|
4.9±0.5 |
100% |
100% |
|
Diazepam |
3 |
3.5±0.5 |
50% |
100% |
|
Diazepam |
10 |
2.4±0.42 |
0%1 |
86% |
|
Phenylephrine |
0.3 |
3.5±0.5 |
60% |
100% |
|
1.0 |
2.5±0.52 |
14%2 |
100% |
|
|
Diazepam + phenylephrine |
3 0.3 |
1.5±0.31 |
0%1 |
28%1 |
|
Diazepam + phenylephrine |
10 0.3 |
0.9±0.21 |
0%1 |
0%1 |
|
Diazepam + phenylephrine + lidocaine, 1 ml 1% |
10 0.3 |
2.0±0.32 |
0%1 |
73% |