Table 2: Effect of amitriptyline, phenylephrine and their combinations on the behavior of rats in the open field test.
|
Substance, mg/kg |
Horizontal activity* |
Vertical activity** |
|
Control (distilled water), i.m. |
24.3±2.7 |
8.1±1.5 |
|
Amitriptyline, 3.0, i.m. Amitriptyline, 10, i.m. Amitriptyline, 30, i.m. |
21.0±2.7 7.1.±0.91 4.0.±0.61 |
8.4±1.8 4.0±0.51 3.2±0.41 |
|
Phenylephrine, 0.02, i.m. |
29.±3.5 |
9.5±1.9 |
|
Amitriptyline, 3.0, i.m. + phenylephrine, 0.02, i.m. |
26±2.9 |
8.7± 1.6 |
|
Amitriptyline, 30, i.m. + phenylephrine, 0.02, i.m. |
20±2.5 |
7.4± 1.6 |
|
Amitriptyline, 30, i.m. + phenylephrine, 0.02 i.m. + lidocaine, 1 ml 1%, i.g. |
4.3.±0.61 |
3.4±0.51 |
|
Amitriptyline, 30, i.m. + phenylephrine, 0.02, i.m. + hexamethonium, 0.2, i.g. |
4.7±0.71 |
3.6±0.61 |
*Total walking time (in seconds).
**Number of stands-up on the hind legs.
1p <0.05 in comparison with the control (Student's t-test).