Table 1: Antidepressant effect of amitriptyline, phenylephrine and their combinations in the Porsolt test.
|
Substance, mg/kg* |
The duration of immobilization in the Porsolt test, sec |
|
Control (distilled water), i.m. |
196±22 |
|
Amitriptyline, 0.3, i.m. Amitriptyline, 1.0, i.m. Amitriptyline, 3.0, i.m. Amitriptyline, 10, i.m. Amitriptyline, 30, i.m. Amitriptyline, 30, i.m.** |
193±20 190±23 187±22 155±18 115±14 65±71 |
|
Phenylephrine, 0.02, i.m Phenylephrine, 0.06, i.m. Phenylephrine, 0.2, i.m. |
191±24 157±19 120±15 |
|
Amitriptyline, 0.3, i.m. + phenylephrine, 0.02, i.m. |
145±16 |
|
Amitriptyline, 1.0, i.m. + phenylephrine, 0.02, i.m. |
111±14 |
|
Amitriptyline, 3.0, i.m. + phenylephrine, 0.02, i.m. |
64±71 |
|
Amitriptyline, 30.0 i.m. + phenylephrine, 0.02, i.m. |
44±52 |
|
Amitriptyline, 3.0, i.m. + phenylephrine, 0.02, i.m. + lidocaine, 1 ml 1%, i.g. |
175±19 |
|
Amitriptyline, 3.0, i.m. + phenylephrine, 0.02, i.m. + hexamethonium, 0.2, i.g. |
171±20 |
|
Amitriptyline, 30, i.m. + phenylephrine, 0.02, i.m. + lidocaine, 1% 1 ml 1%, i.g. |
162±25 |
|
Amitriptyline, 30,0 i.m. + phenylephrine, 0.02, i.m. + hexamethonium, 0.2, i.g. |
152±23 |
*Introduced once for 30 minutes before re-swimming in the Porsolt test.
**Introduced subacute, three times a day (after 1 hour, 5 hours and 23 hours after the first swimming in the Porsolt test).
1p <0.05 compared with the control; 2p <0.01 compared with the control (Student's t-test).